Kuchuluka kwa majini a CYP2C19 a anthu

CYP2C19 ndi imodzi mwa mankhwala ofunikira kwambiri omwe amachotsa ma enzymes m'gulu la CYP450. Ma substrates ambiri amkati ndi pafupifupi 2% ya mankhwala azachipatala amachotsedwa ndi CYP2C19, monga kagayidwe ka zinthu zoletsa kusonkhanitsa ma platelet (monga clopidogrel), zoletsa kupopera kwa proton pump (omeprazole), zoletsa kukomoka, ndi zina zotero. Ma polymorphisms a majini a CYP2C19 alinso ndi kusiyana kwa kagayidwe ka zinthu ka mankhwala ena ofanana nawo. Kusintha kumeneku kwa *2 (rs4244285) ndi *3 (rs4986893) kumayambitsa kutayika kwa ntchito ya enzyme yomwe imachotsedwa ndi jini la CYP2C19 komanso kufooka kwa mphamvu ya kagayidwe ka zinthu, ndikuwonjezera kuchuluka kwa magazi, kotero kuti zimayambitsa zotsatira zoyipa zokhudzana ndi kuchuluka kwa magazi. *17 (rs12248560) ikhoza kuwonjezera ntchito ya enzyme yomwe imachotsedwa ndi jini la CYP2C19, kupanga ma metabolites ogwira ntchito, ndikuwonjezera kuletsa kusonkhanitsa ma platelet ndikuwonjezera chiopsezo cha kutuluka magazi. Kwa anthu omwe ali ndi kagayidwe ka mankhwala pang'onopang'ono, kumwa mankhwala moyenera kwa nthawi yayitali kumabweretsa poizoni komanso zotsatirapo zoyipa: makamaka kuwonongeka kwa chiwindi, kuwonongeka kwa dongosolo la hematopoietic, kuwonongeka kwa dongosolo la mitsempha, ndi zina zotero, zomwe zingayambitse imfa m'milandu yoopsa. Malinga ndi kusiyana kwa kagayidwe ka mankhwala kogwirizana, nthawi zambiri kumagawidwa m'magulu anayi, omwe ndi kagayidwe kachangu kwambiri (UM,*17/*17,*1/*17), kagayidwe kachangu (RM,*1/*1), kagayidwe kapakati (IM, *1/*2, *1/*3), kagayidwe kachangu (PM, *2/*2, *2/*3, *3/*3).