Anthu CYP2C9 ndi VKORC1 Gene Polymorphism

Kufotokozera Kwachidule:

Chidachi chimagwira ntchito pozindikira kuti polymorphism mu m'galasi ya CYP2C9*3 (rs1057910, 1075A>C) ndi VKORC1 (rs9923231, -1639G>A) mu DNA ya genomic ya zitsanzo zamagazi amunthu.


Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Dzina la malonda

HWTS-GE014A-Human CYP2C9 ndi VKORC1 Gene Polymorphism Detection Kit (Fluorescence PCR)

Satifiketi

CE/TFDA

Epidemiology

Warfarin ndi anticoagulant yapakamwa yomwe imagwiritsidwa ntchito kwambiri masiku ano, yomwe cholinga chake ndi kupewa komanso kuchiza matenda a thromboembolic.Komabe, warfarin ili ndi zenera lochepa la chithandizo ndipo imasiyana kwambiri pakati pa mafuko ndi anthu osiyanasiyana.Ziwerengero zawonetsa kuti kusiyana kwa mlingo wokhazikika mwa anthu osiyanasiyana kumatha kupitilira nthawi za 20.The chokhwima anachita magazi kumachitika 15.2% ya odwala kutenga warfarin chaka chilichonse, amene 3.5% kukhala amapha magazi.Kafukufuku wa Pharmacogenomic awonetsa kuti genetic polymorphism ya chandamale enzyme VKORC1 ndi kagayidwe kachakudya ka CYP2C9 ya warfarin ndi chinthu chofunikira chomwe chimakhudza kusiyana kwa mlingo wa warfarin.Warfarin ndi inhibitor yeniyeni ya vitamini K epoxide reductase (VKORC1), motero imalepheretsa kaphatikizidwe ka clotting factor kuphatikiza vitamini K ndipo imapereka anticoagulation.Kafukufuku wambiri wasonyeza kuti jini ya polymorphism ya VKORC1 yolimbikitsa ndiye chinthu chofunikira kwambiri chomwe chimakhudza mpikisano ndi kusiyana kwa anthu pa mlingo wofunikira wa warfarin.Warfarin imapangidwa ndi CYP2C9, ndipo masinthidwe ake amachepetsa kwambiri kagayidwe ka warfarin.Anthu omwe amagwiritsa ntchito warfarin amakhala ndi chiwopsezo chachikulu (kawiri mpaka katatu) chotaya magazi atangoyamba kugwiritsa ntchito.

Channel

FAM VKORC1 (-1639G>A)
CY5 CYP2C9*3
VIC/HEX IC

Magawo aukadaulo

Kusungirako Madzi: ≤-18 ℃
Alumali moyo 12 miyezi
Mtundu wa Chitsanzo Mwazi watsopano wa EDTA anticoagulated
CV ≤5.0%
LoD 1.0ng/μL
Mwatsatanetsatane Palibe kuyanjananso komwe kumayenderana kwambiri ndi ma genome amunthu (mtundu wa CYP2C19 wamunthu, jini ya RPN2 yamunthu);kusintha kwa CYP2C9*13 ndi VKORC1 (3730G>A) kunja kwa kuchuluka kwa zida izi
Zida Zogwiritsira Ntchito Applied Biosystems 7500 Real-Time PCR Systems

Applied Biosystems 7500 Fast Real-Time PCR Systems

QuantStudio®5 Real-Time PCR Systems

SLAN-96P Real-Time PCR Systems

LightCycler®480 Real-Time PCR system

LineGene 9600 Plus Real-Time PCR Detection System

MA-6000 Real-Time Quantitative Thermal Cycler

BioRad CFX96 Real-Time PCR System

BioRad CFX Opus 96 Real-Time PCR System

Kuyenda Ntchito

Regent yovomerezeka yochotsa: Macro & Micro-Test Viral DNA/RNA Kit(HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) ndi Macro & Micro-Test Automatic Nucleic Acid Extractor(HWTS-- 3006).


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