PCT/IL-6 Kuphatikiza

PCT ndiye kalambulabwalo wa calcitonin, womwe ndi glycoprotein wopangidwa ndi 116 amino acid.Kuchuluka kwa mamolekyu ndi pafupifupi 12.8kd.Zilibe m'thupi ntchito.Pansi pa zochitika za thupi, PCT imapangidwa makamaka ndikutulutsidwa ndi maselo a chithokomiro C.Pa matenda a bakiteriya, macrophages ndi monocytes m'chiwindi, lymphocytes ndi endocrine maselo m'mapapo ndi m'mimba minofu kupanga ndi secrete kuchuluka kwa PCT pansi pa zochita za endotoxin, chotupa necrosis factor-α ndi interleukin-6, kuchititsa kuwonjezeka kwambiri. mu seramu PCT milingo.
Interleukin-6 ndi cytokine yomwe imawonetsedwa ndi chitetezo cham'thupi panthawi yovulala koyambirira komanso matenda.Amapangidwa ndi fibroblasts, monocytes / macrophages, T lymphocytes, B lymphocytes, maselo a epithelial, keratinocytes, ndi maselo osiyanasiyana otupa.IL-6 imapangidwa ndi maunyolo awiri a glycoprotein, imodzi ndi unyolo wa α wokhala ndi kulemera kwa molekyulu ya 80kd;chinacho ndi tcheni cha β chokhala ndi molekyulu yolemera 130kd[5].Ngati thupi la munthu limalimbikitsidwa ndi kutupa, milingo ya IL-6 imakwera mwachangu, zomwe zimayimira kuyankha kwachiwindi kwachiwindi ndikulimbikitsa kupanga mapuloteni owopsa monga C-reactive protein (CRP) ndi serum amyloid A (SAA). ).Chifukwa chake, IL-6 ndiye chizindikiritso choyambirira kukwera pamene kutupa kumachitika.