Kuchokera ku Umboni Kupita ku Chida: Malingaliro a Pulofesa Susan Huang pa Kulamulira kwa MRSA ndi Udindo wa POCT ya Molekyulu Yofulumira

—-“MRSA ikadali chiwopsezo chachikulu. Galimoto ya odwala imalimbikitsa kutumiza kwa odwala. Kuwongolera sikufuna njira yokha - komanso liwiro ndi kulondola pamzere wakutsogolo.”

Kuopsa Kosalekeza kwa MRSA

Masiku ano, MRSA ikadali imodzi mwa zifukwa zazikulu zomwe zimayambitsa matenda opatsirana m'chipatala. Mu nkhani yake yayikulu pa ESCMID Global 2026, Pulofesa Susan Huang wa UC Irvine adapereka deta yochititsa chidwi: ku United States kokha, pafupifupiMatenda 120,000 a S. aureus m'magazizimachitika chaka chilichonse, ndianthu pafupifupi 20,000 omwe anamwaliraKugwirizana mwachindunji ndi matendawa. MRSA ndi imodzi mwa zifukwa zazikulu zomwe zimayambitsa matenda opatsirana m'malo ochitira opaleshoni, chibayo, ndi matenda opatsirana m'magazi, ndipo ikupitilira kukhala chifukwa chachikulu cha matenda opatsirana m'chipatala (HAI) mwa ana.

Chomwe chimapangitsa kuti MRSA ikhale yovuta kwambiri kuilamulira ndi kufalikira kwake mosavuta. Ngakhale kuyanjana kwa odwala nthawi zonse ndi omwe amapereka chithandizo kumatha kuipitsa ogwira ntchito zachipatala, mosasamala kanthu za udindo wawo kapena malo omwe ali. Wodwala akangokhala m'dziko la MRSA, mkhalidwe wa wodwalayo ukhoza kukhalapo kwa miyezi kapena zaka, zomwe zimapangitsa kuti kufalikira kwa matendawa kufalikira m'malo onse azaumoyo. Kafukufuku wina wotchulidwa ndi Pulofesa Huang adapeza kuti10–14% ya odwala omwe ali ndi vuto la MRSA amatenga matenda oopsa mkati mwa chaka chimodzi atatulutsidwa kuchipatala.

Njira Zitatu Zowongolera Zomwe Zilipo Panopa: Kuchepetsa, Kulimbana, Kukulitsa

Pulofesa Huang adakonza njira zowongolera MRSA m'zipatala m'njira zitatu:

1. Kusasintha - Njira zoyambira, kulamulira pang'ono
Njira imeneyi ikusintha cholinga chake kuchoka pa "kuchotsa" kupita ku njira zochiritsira zomwe zingagwiritsidwe ntchito m'chipatala chonse, kuphatikizapo ukhondo wa manja, kutsuka khungu ndi mankhwala ophera tizilombo toyambitsa matenda, komanso zida zopewera matenda zomwe zimagwirizana ndi zipangizo. Ndi chithandizo champhamvu choyang'anira, kuchuluka kwa matenda a MRSA kumatha kukhazikika. Komabe, zotsatira zake zimakhala zochepa, ndipo katundu wambiri wa matenda amakhalabe kunja kwa makoma a chipatala.

2. Cholinga - Kuwunika mwachangu + kuchotsa ukoloni kuti mulowererepo molondola
Njira imeneyi imalimbikitsa kuzindikira anthu omwe ali ndi matendawa kudzera mu kuyang'aniridwa mwachangu kuti athe kulowererapo msanga - makamaka chithandizo chochotsa ukoloni. Popeza matenda ambiri a MRSA amachokera ku vuto la mphuno la wodwalayo, kuchotsa ukoloni mwachindunji kungachepetse kwambiri chiopsezo cha matenda. Zakhala zothandiza kwa odwala opaleshoni komanso omwe atulutsidwa kuchipatala. Phindu lake ndi lodziwikiratu, koma njira imeneyi imafuna ndalama zokhazikika.

3. Kukulitsa - Kuphimba kwakukulu kwa maubwino angapo
Njira ya Expand ikuzindikira kuti odwala nthawi zambiri amanyamula tizilombo toyambitsa matenda angapo nthawi imodzi, zomwe zimapangitsa kuti njira yogwiritsira ntchito tizilombo toyambitsa matenda imodzi isagwire ntchito bwino. Njira zoyeretsera khungu monga kuyeretsa khungu ndi mankhwala ophera tizilombo toyambitsa matenda (pogwiritsa ntchito kapena popanda mankhwala a m'mphuno) zitha kuchepetsa kulemera kwa MRSA ndi tizilombo tina nthawi imodzi. Mayesero akuluakulu awonetsa kuti njira imeneyi ndi yothandiza kwambiri pochepetsa MRSA ndi matenda a m'magazi, komanso kupereka chitetezo pochepetsa kuchuluka kwa tizilombo toyambitsa matenda m'thupi la odwala.

Njira Yogwirizanitsa ndi Kugwira Ntchito: Udindo wa Kuyesa Mwachangu komanso Kosavuta Kupeza

Njira zonse zitatu - Relent, Target, ndi Expand - zimagawana zofunikira zofanana:kuzindikira kolondola komanso koyenera kwa MRSA kapena matenda.Popanda kuzindikira mwachangu:

-Relentkusowapompopompondemanga kuti musinthe miyeso yoyambira.

-CholingaSizingatheke kufufuza bwino ndikuchotsa ukoloni popanda kusintha mwachangu.

-Kukulitsaubwino wodziwa njira yoyambira yowunikira momwe zinthu zilili.

Apa ndi pomwe Macro ndi Micro-Test ziliPulogalamu ya POCT yokhazikika ya AIO800+SA & MRSA nucleic acid kuzindikira zidakupereka mlatho wofunikira pakati pa njira zamaphunziro ndi zenizeni zachipatala.

Yankho la Macro & Micro-Test: Kuthandiza Njira IliyonsendiKoreMawonekedwe

-Zolinga:jini la nuc(zapadera kwa S. aureus) +jini la mecA(kukana kwa methicillin)

-Zotsatira muMphindi 30–60(mosiyana ndi masiku awiri mpaka atatu a ulimi)

-Mitundu ya zitsanzo: makoswe, zopopera m'mphuno, zitsanzo za khungu/minofu yofewa

-Kuyika mwachindunji kuchokera m'machubu oyambirira (1.5–12 mL); nthawi yochepa yogwira ntchito

-Ma reagent awiri (amadzimadzi ndi lyophilized) osungira/kunyamula mosavuta

-Kuletsa kuipitsidwa ndi zinthu zokwana 11 (UV, HEPA, kutseka parafini, ndi zina zotero)

-Zikalata: IVDR, NMPA, FDA, MDA

Momwe imathandizira njira iliyonse:

Kupitirira makoma a chipatala

Pulojekiti ya Pulofesa Huang yomwe yangolandira ndalama zokwana mamiliyoni ambiri ikuwonetsa njira yokulirakulira komanso yokulirakulira yopewera matenda: kukulitsa ulamuliro wa MRSA kupitirira chipatala, ndikuyang'ana kwambiri anthu omwe amatenga kachilomboka. Kapangidwe kakang'ono ka AIO800, komwe kamangodzipangira okha kakugwirizana kwambiri ndi lingaliro lomweli. Nsanjayi ndi yoyenera kuthandizira kusintha kwa mayeso olekanitsidwa - zomwe zimathandiza kuzindikira MRSA mwachangu komanso mosavuta m'zipatala zakunja, m'zipatala za anthu ammudzi, komanso m'malo osamalira odwala kunyumba, komwe tsogolo la kupewa matenda likupita.

Kuchokera ku Ndondomeko Kupita ku Yankho

Pulofesa Susan Huang wapereka dongosolo lomveka bwino loletsa matenda padziko lonse lapansi: Relent, Target, and Expand. Koma njira yopanda zida zogwirira ntchito ikadali cholinga chokha. Pulatifomu ya Macro & Micro-Test ya AIO800 POCT ndi zida zodziwira za SA & MRSA zimaperekaliwiro, kuphweka, ndi kupezeka mosavutakufunika kosintha njira izi kukhala zenizeni za tsiku ndi tsiku - muMa ICU, ma wadi onse, ndipo pamapeto pake kupitirira chipatala.