Cyp2C9C9C9 ndi VKORC1 gelmorphism

Warfarin ndi anticoaga pamwambo yemwe amagwiritsidwa ntchito pakamwa pazachipatala pakadali pano, zomwe zimapangidwa makamaka popewa komanso kuchiza matenda a thromboembolic. Komabe, Warfarin ali ndi zenera locheperako komanso limasiyanasiyana pakati pa mitundu ndi anthu osiyanasiyana. Ziwerengero zawonetsa kuti kusiyana kwa mlingo wokhazikika m'mitundu yosiyanasiyana kumatha kukhala kopitilira 20. Kutulutsa magazi kuchitika mu 15.2% ya odwala omwe amatenga nkhondo chaka chilichonse, omwe ali ndi magazini 3.5% amatulutsa magazi. Kafukufuku wa pharmacogenogimic asonyeza kuti majini a polymorphism ya charzyme vyzc1 ndi metabolic enzyme cyp2c9 ya Warfarin ndi chinthu chofunikira chokhudza mlingo wa Warfarin. Warfarin ndi choletsa chapadera cha Vitamini K Epoxide Resose (Vkhorc1), kenako ndikulepheretsa kuvomerezedwa. Maphunziro ambiri asonyeza kuti genelorphism wa vkorc1 wolosera ndi chinthu chofunikira kwambiri chomwe chimakhudza mpikisano ndi kusiyana kwamunthu pamwezi wa Warfarin. Warfarin imapangidwa ndi Cyp2C9, ndipo zosintha zake kwambiri kagayidwe karfarin. Anthu omwe amagwiritsa ntchito Warfarin ali ndi chiopsezo chapamwamba (kawiri mpaka katatu) wa magazi koyambirira kwa ntchito.