Kuchuluka kwa majini a CYP2C9 a anthu ndi VKORC1

Warfarin ndi mankhwala oletsa magazi kuundana omwe amagwiritsidwa ntchito kwambiri pachipatala pakadali pano, omwe cholinga chake chachikulu ndi kupewa ndi kuchiza matenda a thromboembolic. Komabe, warfarin ili ndi nthawi yochepa yochizira ndipo imasiyana kwambiri pakati pa mitundu ndi anthu osiyanasiyana. Ziwerengero zasonyeza kuti kusiyana kwa mlingo wokhazikika mwa anthu osiyanasiyana kungakhale kopitilira nthawi 20. Kutuluka magazi kolakwika kumachitika mwa 15.2% ya odwala omwe amatenga warfarin chaka chilichonse, omwe 3.5% mwa iwo amakhala ndi magazi owopsa. Kafukufuku wa Pharmacogenomic wasonyeza kuti kusinthasintha kwa majini a enzyme VKORC1 ndi enzyme ya metabolic CYP2C9 ya warfarin ndi chinthu chofunikira kwambiri chomwe chimakhudza kusiyana kwa mlingo wa warfarin. Warfarin ndi choletsa chapadera cha vitamini K epoxide reductase (VKORC1), motero chimaletsa kupanga kwa clotting factor komwe kumaphatikizapo vitamini K ndikupereka anticoagulation. Kafukufuku wambiri wasonyeza kuti kusinthasintha kwa majini a VKORC1 promoter ndiye chinthu chofunikira kwambiri chomwe chimakhudza kusiyana kwa mtundu ndi munthu payekha pa mlingo wofunikira wa warfarin. Warfarin imasinthidwa ndi CYP2C9, ndipo masinthidwe ake amachedwetsa kagayidwe ka warfarin. Anthu omwe amagwiritsa ntchito warfarin ali pachiwopsezo chachikulu (kuwirikiza kawiri kapena katatu) cha kutuluka magazi kumayambiriro kwa kugwiritsa ntchito.