Enterococcus yosagonjetsedwa ndi Vancomycin ndi Gene yosagonjetsedwa ndi mankhwala

Kukana Mankhwala kumadziwikanso kuti kukana mankhwala, kumatanthauza kukana kwa mabakiteriya ku mphamvu ya mankhwala opha tizilombo toyambitsa matenda. Kukana mankhwala kukayamba, mphamvu ya mankhwala opha tizilombo toyambitsa matenda imachepa kwambiri. Kukana Mankhwala kumagawidwa m'magulu awiri: kukana kwa mkati ndi kukana komwe kumapezedwa. Kukana kwa mkati kumatsimikiziridwa ndi majini a chromosome a bakiteriya, omwe amaperekedwa kuchokera ku mibadwomibadwo kupita ku mibadwomibadwo, ndipo sasintha. Kukana kumeneku kumachitika chifukwa chakuti atakhudzana ndi maantibayotiki, mabakiteriya amasintha njira zawo zamagetsi kuti asaphedwe ndi maantibayotiki.

Madzi a VanA ndi VanB omwe amalimbana ndi vancomycin ndi omwe amalimbana ndi mankhwala, pomwe VanA amawonetsa kukana kwambiri vancomycin ndi teicoplanin, VanB amawonetsa kukana kosiyanasiyana kwa vancomycin, ndipo amakhudzidwa ndi teicoplanin. Vancomycin nthawi zambiri imagwiritsidwa ntchito pochiza matenda a Gram-positive bacteria, koma chifukwa cha kubuka kwa vancomycin-resistant enterococci (VRE), makamaka enterococcus faecalis ndi enterococcus faecium, zomwe zimaposa 90%, zabweretsa zovuta zatsopano pa chithandizo chamankhwala. Pakadali pano, palibe mankhwala enieni oletsa mabakiteriya ochizira VRE. Kuphatikiza apo, VRE imathanso kutumiza majini olimbana ndi mankhwala ku enterococci ina kapena mabakiteriya ena a Gram-positive.