Lingaliro la chotupa
Chotupa ndi chamoyo chatsopano chopangidwa ndi kuchuluka kwachilendo kwa maselo m'thupi, omwe nthawi zambiri amawonekera ngati minofu yachilendo (mkanda) m'dera la thupi. Kupanga chotupa ndi chifukwa cha vuto lalikulu la kukula kwa maselo pansi pa zochitika zosiyanasiyana za tumorigenic. Kuchulukana kwachilendo kwa maselo omwe amatsogolera kupanga chotupa kumatchedwa neoplastic proliferation.
Mu 2019, Cancer Cell idasindikiza nkhani posachedwa. Ofufuza adapeza kuti metformin imatha kuletsa kukula kwa chotupa m'malo osala kudya, ndipo adati njira ya PP2A-GSK3β-MCL-1 ikhoza kukhala chandamale chatsopano chochizira chotupa.
Kusiyana kwakukulu pakati pa chotupa chosaopsa ndi chotupa choopsa
Chotupa choopsa: kukula pang'onopang'ono, kapisozi, kukula kwa kutupa, kutsetsereka mpaka kukhudza, malire omveka bwino, palibe metastasis, nthawi zambiri zabwino, zizindikiro za psinjika m'deralo, kawirikawiri palibe thupi lonse, nthawi zambiri sizimayambitsa imfa ya odwala.
Chotupa choopsa (khansa): kukula mofulumira, kukula kosautsa, kumamatira ku minofu yozungulira, kulephera kusuntha pamene kukhudzidwa, malire osadziwika bwino, metastasis yosavuta, kubwereza kosavuta pambuyo pa chithandizo, kutentha thupi, kusafuna kudya kumayambiriro, kuchepa thupi, kuchepa kwakukulu, kuchepa kwa magazi m'thupi ndi malungo kumapeto kwa nthawi, ndi zina zotero.
"Chifukwa chakuti zotupa zabwino ndi zotupa zoopsa sizingokhala ndi zizindikiro zosiyana zachipatala, koma chofunika kwambiri, matendawa ndi osiyana, kotero mutapeza chotupa m'thupi lanu ndi zizindikiro zomwe zili pamwambazi, muyenera kupeza uphungu wachipatala panthawi yake."
Payokha mankhwala chotupa
Human Genome Project ndi International Cancer Genome Project
Human Genome Project, yomwe idakhazikitsidwa mwalamulo ku United States mu 1990, ikufuna kumasula ma code pafupifupi 100,000 m'thupi la munthu ndikujambula mitundu yosiyanasiyana ya majini amunthu.
Mu 2006, International Cancer Genome Project, yomwe idakhazikitsidwa pamodzi ndi mayiko ambiri, ndi kafukufuku wina wamkulu wa sayansi pambuyo pa Human Genome Project.
Mavuto aakulu mu chithandizo cha chotupa
Kuzindikira kwapadera ndi chithandizo = Kuzindikira kwapadera + mankhwala omwe amatsata
Kwa odwala ambiri omwe akudwala matenda omwewo, njira yochiritsira ndiyo kugwiritsa ntchito mankhwala omwewo komanso mlingo wofanana, koma kwenikweni, odwala osiyanasiyana amasiyana kwambiri ndi zotsatira za chithandizo ndi zotsatira zoyipa, ndipo nthawi zina kusiyana kumeneku kumakhala koopsa.
Thandizo lamankhwala lomwe limaperekedwa limakhala ndi kupha kosankha bwino kwa maselo otupa popanda kupha kapena kuwononga maselo abwinobwino, omwe amakhala ndi zotsatirapo zazing'ono, zomwe zimapangitsa kuti moyo ukhale wabwino komanso machiritso a odwala.
Chifukwa mankhwala omwe amawathandizira amapangidwa kuti azilimbana ndi mamolekyu omwe amawatsata, ndikofunikira kuzindikira majini otupa ndikuwona ngati odwala ali ndi zolinga zofanana asanamwe mankhwala, kuti athe kuchiritsa.
Kuzindikira jini ya chotupa
Kuzindikira jini ya chotupa ndi njira yowunikira ndikutsata DNA/RNA ya maselo otupa.
Kufunika kozindikira jini ya chotupa ndikuwongolera kusankha kwamankhwala kwamankhwala osokoneza bongo (mankhwala omwe akutsata, ma immune checkpoint inhibitors ndi Edzi ina yatsopano, chithandizo mochedwa), komanso kulosera zam'tsogolo ndi kubwereranso.
Mayankho operekedwa ndi Acer Macro & Micro-Test
Human EGFR Gene 29 Mutations Detection Kit (Fluorescence PCR）
Amagwiritsidwa ntchito pozindikira zakusintha wamba mu exon 18-21 ya EGFR jini mwa odwala omwe si ang'onoang'ono a khansa ya m'mapapo ya m'mapapo.
1. Kukhazikitsidwa kwa kayendetsedwe ka khalidwe lamkati mwadongosolo kungayang'ane mozama ndondomeko yoyesera ndikuwonetsetsa khalidwe loyesera.
2. Kukhudzika kwakukulu: kuchuluka kwa kusintha kwa 1% kumatha kuzindikirika mokhazikika kumbuyo kwa 3ng / μL yakuthengo yamtundu wa nucleic acid reaction solution.
3. Zapamwamba kwambiri: palibe kusinthana ndi zotsatira za DNA yamtundu wa anthu wamtchire ndi mitundu ina yosasinthika.
KRAS 8 Mutation Detection Kit (Fluorescence PCR)
Mitundu isanu ndi itatu ya masinthidwe mu ma codon 12 ndi 13 a jini ya K-ras omwe amagwiritsidwa ntchito pozindikira zamtundu wa DNA wotengedwa m'magawo a paraffin ophatikizidwa mu vitro.
1. Kukhazikitsidwa kwa kayendetsedwe ka khalidwe lamkati mwadongosolo kungayang'ane mozama ndondomeko yoyesera ndikuwonetsetsa khalidwe loyesera.
2. Kukhudzika kwakukulu: kuchuluka kwa kusintha kwa 1% kumatha kuzindikirika mokhazikika kumbuyo kwa 3ng / μL yakuthengo yamtundu wa nucleic acid reaction solution.
3. Zapamwamba kwambiri: palibe kusinthana ndi zotsatira za DNA yamtundu wa anthu wamtchire ndi mitundu ina yosasinthika.
Human ROS1 Fusion Gene Mutation Detection Kit (Fluorescence PCR)
Amagwiritsidwa ntchito pozindikira mitundu 14 yosinthika ya jini ya ROS1 fusion mwa odwala omwe si ang'onoang'ono a khansa ya m'mapapo ya m'mapapo.
1. Kukhazikitsidwa kwa kayendetsedwe ka khalidwe lamkati mwadongosolo kungayang'ane mozama ndondomeko yoyesera ndikuwonetsetsa khalidwe loyesera.
2. Kukhudzika kwakukulu: makope a 20 a masinthidwe osakanikirana.
3. Zapamwamba kwambiri: palibe kusinthana ndi zotsatira za DNA yamtundu wa anthu wamtchire ndi mitundu ina yosasinthika.
Anthu EML4-ALK Fusion Gene Mutation Detection Kit (Fluorescence PCR)
Amagwiritsidwa ntchito pozindikira mitundu 12 yosinthika ya EML4-ALK fusion jini mwa odwala omwe si ang'onoang'ono a khansa ya m'mapapo ya m'mapapo.
1. Kukhazikitsidwa kwa kayendetsedwe ka khalidwe lamkati mwadongosolo kungayang'ane mozama ndondomeko yoyesera ndikuwonetsetsa khalidwe loyesera.
2. Kukhudzika kwakukulu: makope a 20 a masinthidwe osakanikirana.
3. Zapamwamba kwambiri: palibe kusinthana ndi zotsatira za DNA yamtundu wa anthu wamtchire ndi mitundu ina yosasinthika.
Human BRAF Gene V600E Mutation Detection Kit (Fluorescence PCR)
Amagwiritsidwa ntchito kuti azindikire kusintha kwa BRAF jini V600E mu zitsanzo za minofu ya parafini ya melanoma yamunthu, khansa yapakhungu, khansa ya chithokomiro ndi khansa ya m'mapapo mu m'galasi.
1. Kukhazikitsidwa kwa kayendetsedwe ka khalidwe lamkati mwadongosolo kungayang'ane mozama ndondomeko yoyesera ndikuwonetsetsa khalidwe loyesera.
2. Kukhudzika kwakukulu: kuchuluka kwa kusintha kwa 1% kumatha kuzindikirika mokhazikika kumbuyo kwa 3ng / μL yakuthengo yamtundu wa nucleic acid reaction solution.
3. Zapamwamba kwambiri: palibe kusinthana ndi zotsatira za DNA yamtundu wa anthu wamtchire ndi mitundu ina yosasinthika.
| Chinthu No | Dzina lazogulitsa | Kufotokozera |
| Chithunzi cha HWTS-TM006 | Anthu EML4-ALK Fusion Gene Mutation Detection Kit (Fluorescence PCR) | 20 mayeso / zida 50 mayeso / zida |
| Mbiri ya HWTS-TM007 | Human BRAF Gene V600E Mutation Detection Kit (Fluorescence PCR) | 24 mayeso / zida 48 mayeso / zida |
| Mbiri ya HWTS-TM009 | Human ROS1 Fusion Gene Mutation Detection Kit (Fluorescence PCR) | 20 mayeso / zida 50 mayeso / zida |
| Chithunzi cha HWTS-TM012 | Human EGFR Gene 29 Mutations Detection Kit (Fluorescence PCR） | 16 mayeso / zida 32 mayeso / zida |
| Chithunzi cha HWTS-TM014 | KRAS 8 Mutation Detection Kit (Fluorescence PCR) | 24 mayeso / zida 48 mayeso / zida |
| Chithunzi cha HWTS-TM016 | Anthu TEL-AML1 Fusion Gene Mutation Detection Kit (Fluorescence PCR) | 24 mayeso / zida |
| Chithunzi cha HWTS-GE010 | Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR) | 24 mayeso / zida |
Nthawi yotumiza: Apr-17-2024