Lingaliro la chotupa
Chotupa ndi chamoyo chatsopano chomwe chimapangidwa ndi kuchulukana kwa maselo m'thupi, komwe nthawi zambiri kumawonekera ngati minofu yosazolowereka (chotupa) m'thupi. Kupangika kwa chotupa kumachitika chifukwa cha kusokonezeka kwakukulu kwa kukula kwa maselo chifukwa cha zinthu zosiyanasiyana zoyambitsa chotupa. Kuchulukana kosazolowereka kwa maselo komwe kumabweretsa chotupa kumatchedwa kuchulukana kwa neoplastic.
Mu 2019, Cancer Cell inafalitsa nkhani posachedwapa. Ofufuza adapeza kuti metformin imatha kuletsa kukula kwa chotupa m'thupi la munthu akamasala kudya, ndipo adanenanso kuti njira ya PP2A-GSK3β-MCL-1 ikhoza kukhala njira yatsopano yochizira chotupa.
Kusiyana kwakukulu pakati pa chotupa chosaopsa ndi chotupa choipa
Chotupa chosaopsa: kukula pang'onopang'ono, kapisozi, kutupa, kutsetsereka mpaka kukhudza, malire omveka bwino, palibe kufalikira kwa matendawa, nthawi zambiri zizindikiro zabwino za kupsinjika kwapafupi, nthawi zambiri thupi lonse silikhalapo, nthawi zambiri silimayambitsa imfa ya odwala.
Chotupa choopsa (khansa): kukula mofulumira, kukula kosalekeza, kumamatira ku minofu yozungulira, kulephera kusuntha ikakhudzidwa, malire osamveka bwino, kufalikira mosavuta kwa matendawa, kubwereranso mosavuta pambuyo pa chithandizo, kutentha thupi pang'ono, kusafuna kudya koyambirira, kuchepa thupi, kufooka kwambiri, kuchepa magazi m'thupi ndi kutentha thupi kumapeto kwa gawo, ndi zina zotero. Ngati sichichiritsidwa pa nthawi yake, nthawi zambiri chimabweretsa imfa.
"Chifukwa zotupa zosaopsa ndi zotupa zoyipa sizimangokhala ndi zizindikiro zosiyana zachipatala, komanso chofunika kwambiri, kuti zizindikiro zake zimakhala zosiyana, choncho mukangopeza chotupa m'thupi lanu ndi zizindikiro zomwe zili pamwambapa, muyenera kufunafuna upangiri wa dokotala nthawi yake."
Chithandizo cha chotupa payekha
Pulojekiti ya Genome ya Anthu ndi Pulojekiti ya Genome ya Khansa Yapadziko Lonse
Pulojekiti ya Human Genome Project, yomwe idakhazikitsidwa mwalamulo ku United States mu 1990, cholinga chake ndi kutsegula ma code onse a majini pafupifupi 100,000 m'thupi la munthu ndikujambula mitundu yosiyanasiyana ya majini a anthu.
Mu 2006, International Cancer Genome Project, yomwe idayambitsidwa limodzi ndi mayiko ambiri, ndi kafukufuku wina waukulu wasayansi pambuyo pa Human Genome Project.
Mavuto akuluakulu mu chithandizo cha khansa
Kuzindikira ndi kuchiza matenda payekhapayekha = Kuzindikira matenda payekhapayekha + mankhwala ofunikira
Kwa odwala ambiri omwe ali ndi matenda omwewo, njira yochizira ndi kugwiritsa ntchito mankhwala omwewo ndi mlingo wofanana, koma kwenikweni, odwala osiyanasiyana ali ndi kusiyana kwakukulu pa zotsatira za chithandizo ndi zotsatira zoyipa, ndipo nthawi zina kusiyana kumeneku kumakhala koopsa.
Mankhwala ochizira matenda a khansa ali ndi mawonekedwe osankha bwino maselo a chotupa popanda kupha kapena kuwononga maselo abwinobwino nthawi zambiri, ndi zotsatirapo zochepa, zomwe zimapangitsa kuti moyo wa odwala ukhale wabwino komanso kuti alandire chithandizo chabwino.
Popeza chithandizo cholunjika chimapangidwa kuti chiukire mamolekyu enaake, ndikofunikira kuzindikira majini a chotupa ndikuwona ngati odwala ali ndi zolinga zofanana asanamwe mankhwala, kuti athe kuchiritsa.
Kuzindikira majini a chotupa
Kuzindikira majini a chotupa ndi njira yowunikira ndikutsata DNA/RNA ya maselo a chotupa.
Kufunika kwa kuzindikira majini a chotupa ndikuwongolera kusankha mankhwala ochiritsira (mankhwala ofunikira, zoletsa chitetezo chamthupi ndi zina zatsopano za AIDS, chithandizo cha mochedwa), komanso kuneneratu za nthawi yomwe matendawa adzayambire komanso momwe angabwererenso.
Mayankho operekedwa ndi Acer Macro & Micro-Test
Kiti Yodziwira Kusintha kwa Ma EGFR Gene 29 ya Munthu (Fluorescence PCR)）
Amagwiritsidwa ntchito pozindikira kusintha kwa majini komwe kumachitika mu exon 18-21 ya EGFR mwa odwala khansa ya m'mapapo ya anthu omwe si ang'onoang'ono mu vitro.
1. Kuyambitsa njira yowongolera khalidwe la mkati mwa dongosolo kungathe kuyang'anira bwino njira yoyesera ndikutsimikizira khalidwe la kuyesa.
2. Kuzindikira kwambiri: kuchuluka kwa kusintha kwa 1% kumatha kuzindikirika bwino kumbuyo kwa yankho la 3ng/μL wild-type nucleic acid reaction.
3. Kulondola kwambiri: palibe kuyanjana komwe kumachitika ndi zotsatira za DNA ya genomic ya munthu wamtundu wakuthengo ndi mitundu ina yosinthika.
KRAS 8 Mutations Detection Kit (Fluorescence PCR)
Mitundu isanu ndi itatu ya masinthidwe a majini a K-ras mu ma codon 12 ndi 13 omwe amagwiritsidwa ntchito pozindikira DNA yochokera ku magawo a matenda omwe amaphatikizidwa ndi paraffin mwa anthu mu vitro.
1. Kuyambitsa njira yowongolera khalidwe la mkati mwa dongosolo kungathe kuyang'anira bwino njira yoyesera ndikutsimikizira khalidwe la kuyesa.
2. Kuzindikira kwambiri: kuchuluka kwa kusintha kwa 1% kumatha kuzindikirika bwino kumbuyo kwa yankho la 3ng/μL wild-type nucleic acid reaction.
3. Kulondola kwambiri: palibe kuyanjana komwe kumachitika ndi zotsatira za DNA ya genomic ya munthu wamtundu wakuthengo ndi mitundu ina yosinthika.
Kiti Yodziwira Kusintha kwa Majini a Anthu ya ROS1 (Fluorescence PCR)
Amagwiritsidwa ntchito pozindikira mitundu 14 ya kusintha kwa majini a ROS1 mwa odwala khansa ya m'mapapo ya anthu omwe si ang'onoang'ono mu vitro.
1. Kuyambitsa njira yowongolera khalidwe la mkati mwa dongosolo kungathe kuyang'anira bwino njira yoyesera ndikutsimikizira khalidwe la kuyesa.
2. Kuzindikira kwambiri: makope 20 a kusintha kwa fusion.
3. Kulondola kwambiri: palibe kuyanjana komwe kumachitika ndi zotsatira za DNA ya genomic ya munthu wamtundu wakuthengo ndi mitundu ina yosinthika.
Kiti Yodziwira Kusintha kwa Majini a EML4-ALK ya Munthu (Fluorescence PCR)
Amagwiritsidwa ntchito pozindikira mitundu 12 ya kusintha kwa majini a EML4-ALK mwa odwala khansa ya m'mapapo ya anthu omwe si ang'onoang'ono m'thupi.
1. Kuyambitsa njira yowongolera khalidwe la mkati mwa dongosolo kungathe kuyang'anira bwino njira yoyesera ndikutsimikizira khalidwe la kuyesa.
2. Kuzindikira kwambiri: makope 20 a kusintha kwa fusion.
3. Kulondola kwambiri: palibe kuyanjana komwe kumachitika ndi zotsatira za DNA ya genomic ya munthu wamtundu wakuthengo ndi mitundu ina yosinthika.
Kiti Yodziwira Kusintha kwa Madzi ya BRAF Gene V600E ya Munthu (Fluorescence PCR)
Amagwiritsidwa ntchito kuzindikira bwino kusintha kwa jini la BRAF V600E m'zitsanzo za minofu ya melanoma ya anthu, khansa ya m'matumbo, khansa ya chithokomiro ndi khansa ya m'mapapo m'thupi.
1. Kuyambitsa njira yowongolera khalidwe la mkati mwa dongosolo kungathe kuyang'anira bwino njira yoyesera ndikutsimikizira khalidwe la kuyesa.
2. Kuzindikira kwambiri: kuchuluka kwa kusintha kwa 1% kumatha kuzindikirika bwino kumbuyo kwa yankho la 3ng/μL wild-type nucleic acid reaction.
3. Kulondola kwambiri: palibe kuyanjana komwe kumachitika ndi zotsatira za DNA ya genomic ya munthu wamtundu wakuthengo ndi mitundu ina yosinthika.
| Nambala ya Chinthu | Dzina la Chinthu | Kufotokozera |
| HWTS-TM006 | Kiti Yodziwira Kusintha kwa Majini a EML4-ALK ya Munthu (Fluorescence PCR) | Mayeso 20/zida Mayeso 50/zida |
| HWTS-TM007 | Kiti Yodziwira Kusintha kwa Madzi ya BRAF Gene V600E ya Munthu (Fluorescence PCR) | Mayeso 24/zida Mayeso 48/zida |
| HWTS-TM009 | Kiti Yodziwira Kusintha kwa Majini a Anthu ya ROS1 (Fluorescence PCR) | Mayeso 20/zida Mayeso 50/zida |
| HWTS-TM012 | Kiti Yodziwira Kusintha kwa Ma EGFR Gene 29 ya Munthu (Fluorescence PCR)） | Mayeso 16/zida Mayeso 32/zida |
| HWTS-TM014 | KRAS 8 Mutations Detection Kit (Fluorescence PCR) | Mayeso 24/zida Mayeso 48/zida |
| HWTS-TM016 | Kiti Yodziwira Kusintha kwa Majini a TEL-AML1 a Munthu (Fluorescence PCR) | Mayeso 24/zida |
| HWTS-GE010 | Kiti Yodziwira Kusintha kwa Majini a BCR-ABL a Munthu (Fluorescence PCR) | Mayeso 24/zida |
Nthawi yotumizira: Epulo-17-2024