Kusintha kwa mfundo mu jini ya KRAS kumakhudzidwa ndi mitundu yosiyanasiyana ya zotupa za anthu, ndipo kuchuluka kwa kusintha kwa maselo kumakhala pafupifupi 17%–25% pa mitundu yonse ya zotupa, 15%–30% mu khansa ya m'mapapo, ndi 20%–50% mu khansa ya m'matumbo. Kusintha kumeneku kumayendetsa kukana chithandizo ndi kupita patsogolo kwa chotupa kudzera mu njira yofunika kwambiri: puloteni ya P21 yomwe KRAS imayika mu KRAS imagwira ntchito pansi pa njira yolumikizirana ya EGFR. KRAS ikasinthidwa, imayambitsa nthawi zonse kulumikiza maselo pansi, zomwe zimapangitsa kuti mankhwala opita ku EGFR asagwire ntchito bwino komanso zimapangitsa kuti maselo owopsa achuluke. Zotsatira zake, kusintha kwa maselo a KRAS kumagwirizanitsidwa ndi kukana kwa EGFR tyrosine kinase inhibitors mu khansa ya m'mapapo komanso mankhwala oletsa anti-EGFR antibody mu khansa ya m'matumbo.

Mu 2008, National Comprehensive Cancer Network (NCCN) idakhazikitsa malangizo azachipatala omwe amalimbikitsa kuyezetsa kusintha kwa KRAS kwa odwala onse omwe ali ndi khansa ya m'matumbo yofalikira (mCRC) asanalandire chithandizo. Malangizowa akuwonetsa kuti kusintha kwakukulu kwa KRAS kumachitika mu codons 12 ndi 13 ya exon 2. Chifukwa chake, kuzindikira mwachangu komanso molondola kwa kusintha kwa KRAS ndikofunikira kuti pakhale chithandizo choyenera chachipatala.

Chifukwa Chake Kuyesa kwa KRAS Ndikofunikira KwambiriMkufalikira kwa matendaCmalo ozunguliraCancer(mCRC)

Khansa ya m'matumbo (CRC) si matenda amodzi okha koma gulu la mitundu yosiyanasiyana ya mamolekyu. Kusintha kwa KRAS—komwe kumapezeka mwa odwala pafupifupi 40–45% a CRC—kumagwira ntchito ngati kusintha kosalekeza, kulimbikitsa kukula kwa khansa popanda zizindikiro zakunja. Kwa odwala omwe ali ndi mCRC, momwe KRAS ilili imatsimikizira mphamvu ya ma antibodies a anti-EGFR monoclonal monga Cetuximab ndi Panitumumab:

KRAS yamtundu wa Wild:Odwala angapindule ndi chithandizo chotsutsana ndi EGFR.

KRAS Yosinthika:Odwala sapindula ndi mankhwala amenewa, zomwe zimapangitsa kuti pakhale zotsatirapo zosafunikira, ndalama zambiri, komanso kuchedwa kwa chithandizo chogwira ntchito.

Kuyesa kolondola komanso koyenera kwa KRAS ndiye maziko a kukonzekera chithandizo chamunthu payekha.

Vuto Lozindikira: Kusiyanitsa Chizindikiro cha Kusintha

Njira zachikhalidwe nthawi zambiri sizimazindikira kusintha kwa majini komwe kumakhala kochepa, makamaka m'zitsanzo zomwe zili ndi chotupa chochepa kapena zitachotsedwa mu calcium. Vuto lili pakusiyanitsa chizindikiro cha DNA chofooka poyerekeza ndi maziko apamwamba achilengedwe - monga momwe zimakhalira ndi singano mu udzu. Zotsatira zosalondola zingayambitse chithandizo cholakwika komanso zotsatira zake zimakhala zovuta.

Yankho Lathu: Yopangidwa Mwaluso Kuti Izindikire Kusintha kwa Masinthidwe Modalirika

KRAS Mutation Detection Kit yathu imagwiritsa ntchito ukadaulo wapamwamba kuti ithetse zofooka izi, kupereka kulondola kwapadera komanso kudalirika kwa chitsogozo cha chithandizo cha mCRC.

Momwe Ukadaulo Wathu Umathandizira Kuchita Bwino Kwambiri

• Ukadaulo Wowonjezera wa ARMS (Njira Yosinthira Ma Refractory): Umamangidwa pa ukadaulo wa ARMS, womwe umaphatikizapo ukadaulo wowonjezera wa enhancer kuti uwonjezere kuzindikira kwapadera.
• Kuonjezera Enzymatic: Imagwiritsa ntchito ma endonuclease oletsa kugaya ma genome ambiri a anthu, kupulumutsa mitundu yosinthika, motero imathandizira kuzindikira ndikuchepetsa kukulitsa kosakhala kwapadera chifukwa cha ma genome ambiri.
• Kuletsa Kutentha: Kumayambitsa njira zinazake zotenthetsera mu PCR, zomwe zimapangitsa kuti pakhale kusiyana pakati pa ma mutant primers ndi ma templates amtundu wa wild, motero kuchepetsa maziko amtundu wa wild ndikuwonjezera kuzindikira.
• Kuzindikira Kwambiri: Amazindikira molondola DNA yosinthika ya 1%.
• Kulondola Kwambiri: Imagwiritsa ntchito miyezo yamkati ndi enzyme ya UNG kuti ipewe zotsatira zabodza komanso zoyipa.
• Zosavuta komanso Zachangu: Zimatha kuyesa mu mphindi pafupifupi 120, pogwiritsa ntchito machubu awiri ochitirapo kanthu kuti zithandize kuzindikira masinthidwe asanu ndi atatu osiyanasiyana, zomwe zimapangitsa kuti pakhale zotsatira zenizeni komanso zodalirika.
• Kugwirizana kwa Chida: Kumagwirizana ndi zida zosiyanasiyana za PCR.

Mankhwala olondola a khansa ya m'matumbo amayamba ndi kuzindikira bwino maselo. Pogwiritsa ntchito KRAS Mutation Detection Kit yathu, labotale yanu ikhoza kupereka zotsatira zenizeni komanso zothandiza zomwe zimapangitsa kuti wodwalayo alandire chithandizo.

Limbikitsani labu yanu ndi ukadaulo wodalirika komanso wapamwamba—ndipo yambitsani chisamaliro chenicheni chaumwini.

Lumikizanani nafe: malonda@mmtest.Com

Dziwani zambiri zokhudza kuphatikiza njira yotsogola iyi mu njira yanu yodziwira matenda.

#Chotupa cha m'mimba #Khansa #DNA #Kusintha kwa DNA #Kulondola #Kulunjika #Kuchiza #Khansa

Kutsegula Mankhwala Olondola mu Khansa ya M'mimba

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