Kusintha kwa mfundo mu jini ya KRAS kumakhudzidwa ndi zotupa zosiyanasiyana za anthu, zomwe zimasintha pafupifupi 17% -25% pamitundu yonse ya chotupa, 15% -30% mu khansa ya m'mapapo, ndi 20% -50% mu khansa yapakhungu. Kusintha kumeneku kumayendetsa kukana kwa chithandizo ndikukula kwa chotupa kudzera m'makina ofunikira: puloteni ya P21 yosungidwa ndi KRAS imagwira ntchito kumunsi kwa njira yolumikizira EGFR. KRAS ikasinthidwa, imayendetsa mosalekeza ma sign apansi pamtsinje, kupangitsa kuti machiritso omwe amatsata kumtunda kwa EGFR akhale osagwira ntchito ndikupangitsa kuti ma cell oyipa azichulukirachulukira. Zotsatira zake, masinthidwe a KRAS amalumikizidwa ndi kukana EGFR tyrosine kinase inhibitors mu khansa ya m'mapapo komanso anti-EGFR antibody therapies mu colorectal cancer.

Mu 2008, National Comprehensive Cancer Network (NCCN) idakhazikitsa malangizo azachipatala olimbikitsa kuyezetsa kusintha kwa KRAS kwa odwala onse omwe ali ndi metastatic colorectal cancer (mCRC) asanalandire chithandizo. Malangizowo akuwonetsa kuti zambiri zoyambitsa kusintha kwa KRAS zimachitika mu codons 12 ndi 13 za exon 2. Choncho, kuzindikira kusintha kwa KRAS mofulumira komanso kolondola n'kofunika kuti kutsogolera chithandizo choyenera chachipatala.

Chifukwa chiyani Kuyesa kwa KRAS NdikofunikiraMetastaticColorectalCkhansa(mCRC)

Khansara ya colorectal (CRC) si matenda amodzi koma gulu lamitundu yosiyana kwambiri. Kusintha kwa KRAS-komwe kuli pafupifupi 40-45% ya odwala CRC-amakhala ngati "on" nthawi zonse, kulimbikitsa kukula kwa khansa popanda zizindikiro zakunja. Kwa odwala omwe ali ndi mCRC, mawonekedwe a KRAS amatsimikizira mphamvu ya anti-EGFR monoclonal antibodies monga Cetuximab ndi Panitumumab:

Mtundu Wakutchire KRAS:Odwala amatha kupindula ndi chithandizo cha anti-EGFR.

Mutant KRAS:Odwala sapindula chilichonse kuchokera kwa othandizirawa, kuyika zovuta zoyipa, kuchuluka kwa ndalama, komanso kuchedwa kwa chithandizo chamankhwala.

Kuyesa kolondola komanso kovutirapo kwa KRAS ndiye mwala wapangodya wakukonzekera kwamunthu payekha.

Vuto Lozindikira: Kupatula Chizindikiro Chakusintha

Njira zachikhalidwe nthawi zambiri zimakhala zopanda chidwi pakusintha kwachulukidwe kocheperako, makamaka pazitsanzo zokhala ndi chotupa chochepa kapena pambuyo pochotsa. Vuto lagona pa kusiyanitsa chizindikiro cha DNA chosasintha kwambiri ndi zinthu zakuthengo—mofanana ndi kupeza singano mu mulu wa udzu. Zotsatira zolakwika zingayambitse chithandizo chosadziwika bwino komanso zotsatira zosokoneza.

Yankho Lathu: Precision-Engineered for Confident Mutation Detection

KRAS Mutation Detection Kit yathu imaphatikiza matekinoloje apamwamba kuti athe kuthana ndi izi, kupereka kulondola kwapadera komanso kudalirika kwa chitsogozo chamankhwala cha mCRC.

Momwe Tekinoloje Yathu Imatsimikizirira Kuchita Kwapamwamba

• Tekinoloje yowonjezereka ya ARMS (Amplification Refractory Mutation System): Imamanga paukadaulo wa ARMS, kuphatikiza ukadaulo wowonjezera kuti uwonjezere kuzindikirika.
• Kulemera kwa Enzymatic: Imagwiritsira ntchito ma endonuclease oletsa kugaya ma genome ambiri akutchire, kupulumutsa mitundu yosinthika, motero kumathandizira kuzindikira ndikuchepetsa kukulitsa komwe sikunatchulidwe chifukwa cha mbiri yakale kwambiri.
• Kutsekereza Kutentha: Kumayambitsa masitepe apadera a kutentha mu ndondomeko ya PCR, kuchititsa kusagwirizana pakati pa zoyambira zosinthika ndi ma tempuleti akutchire, potero kumachepetsa maziko amtchire ndikuwongolera kuzindikira.
• Kukhudzika Kwambiri: Imazindikira molondola ngati 1% mutant DNA.
• Kulondola Kwambiri: Amagwiritsa ntchito miyezo yamkati ndi UNG enzyme kuti ateteze zotsatira zabodza komanso zoyipa.
• Zosavuta komanso Zofulumira: Zimamaliza kuyesa pafupifupi mphindi 120, pogwiritsa ntchito machubu awiri ochitira zinthu kuti zithandizire kuzindikira masinthidwe asanu ndi atatu, kutulutsa zolinga ndi zotsatira zodalirika.
• Kugwirizana kwa Chida: Zimasinthira ku zida zosiyanasiyana za PCR.

Mankhwala olondola a khansa ya m'matumbo amayamba ndi kuwunika kolondola kwa maselo. Potengera KRAS Mutation Detection Kit yathu, labotale yanu imatha kupereka zotsatira zotsimikizika, zomwe zingasinthe mwachindunji njira yamankhwala ya wodwala.

Limbikitsani labu yanu ndiukadaulo wodalirika, wotsogola-ndikuthandizira chisamaliro chamunthu.

Lumikizanani nafe: malonda@mmtest.Com

Phunzirani zambiri za kuphatikiza yankho lapamwambali mumayendedwe anu ozindikira.

#Colorectal #Cancer #DNA #Mutation #Precision #Targeted #Treatment #Cancer

Kutsegula Precision Medicine mu Colorectal Cancer

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