Kusintha kwa C. Kuzindikira Kusiyanasiyana: Kukwaniritsa Kuzindikira kwa Maselo Omwe Amagwira Ntchito Mwadongosolo, Chitsanzo Choyankha

Kodi n’chiyani chimayambitsa matenda a C. Diff?

1. Matenda a diff amayamba chifukwa cha bakiteriya wotchedwa Clostridioides difficile (C. difficile), yemwe nthawi zambiri amakhala m'matumbo osavulaza. Komabe, pamene mabakiteriya m'matumbo asokonezeka, nthawi zambiri amagwiritsa ntchito maantibayotiki ambiri,C. zovutaimatha kukula kwambiri ndikupanga poizoni, zomwe zimapangitsa kuti matenda ayambe.

Bakiteriya iyi imapezeka m'mitundu yonse iwiri ya poizoni ndi yopanda poizoni, koma mitundu yokha ya poizoni (toxin A ndi B) ndiyo imayambitsa matenda. Imayambitsa kutupa mwa kusokoneza maselo a m'mimba. Toxin A makamaka ndi enterotoxin yomwe imawononga mkati mwa matumbo, kuwonjezera kulowa kwa madzi, ndikukopa maselo oteteza thupi omwe amatulutsa ma cytokines otupa. Toxin B, cytotoxin yamphamvu kwambiri, imalimbana ndi actin cytoskeleton ya maselo, zomwe zimapangitsa kuti maselo azizungulira, azigawikana, ndipo pamapeto pake kufa kwa maselo. Pamodzi, poizoniyu amachititsa kuwonongeka kwa minofu ndi chitetezo champhamvu cha mthupi, chomwe chimawonekera ngati colitis, kutsegula m'mimba, komanso nthawi zina, pseudomembranous colitis - kutupa kwakukulu kwa m'matumbo.

Kodi C. Diff imafalikira bwanji?

1. Matendawa amafalikira mosavuta. Amapezeka m'zipatala, nthawi zambiri amapezeka m'ma ICU, m'manja mwa ogwira ntchito kuchipatala, pansi pa zipatala ndi m'manja, pa ma thermometers amagetsi, ndi zida zina zachipatala…

Zinthu Zoopsa za Matenda a C. Diff

• Kugonekedwa m'chipatala kwa nthawi yayitali;
• mankhwala oletsa tizilombo toyambitsa matenda;
• Mankhwala a chemotherapy;
• Opaleshoni yaposachedwa (manja a m'mimba,njira yodutsa m'mimbaopaleshoni ya m'matumbo);
• Zakudya za m'mimba ndi m'mphuno;
• Matenda a C. diff asanachitike;

Zizindikiro za matenda a C. Diff

Matenda a C. diff angakhale osasangalatsa kwambiri. Anthu ambiri amakhala ndi kutsegula m'mimba kosalekeza komanso kusasangalala m'mimba. Zizindikiro zodziwika bwino ndi izi:kutsegula m'mimba, kupweteka m'mimba, nseru, kusowa chilakolako cha chakudya, malungo.

Pamene matenda a C. diff akuchulukirachulukira, padzakhala chitukuko cha mtundu wovuta kwambiri wa C. diff wotchedwamatenda a m'matumbo, matenda a m'mimba otchedwa pseudomembranous enteritis komanso ngakhale imfa.

Kuzindikira Matenda a C. Diff

Chikhalidwe cha Mabakiteriya: Wofatsa komanthawi yochuluka (masiku 2-5), sangathe kusiyanitsamitundu ya poizoni ndi yopanda poizoni;

Chikhalidwe cha Poizoni:imazindikira mitundu ya poizoni yomwe imayambitsa matenda koma imatenga nthawi (masiku 3-5) komanso yosakhudzidwa kwambiri;

Kuzindikira GDH:mwachangu (maola 1-2) komanso yotsika mtengo, yodziwika bwino koma singathe kusiyanitsa mitundu ya poizoni ndi yosakhala poizoni;

Kuyesa Kusagwiritsa Ntchito Mankhwala Oletsa Kuopsa kwa Matenda a Cell Cytotoxicity (CCNA):Imazindikira poizoni A ndi B ndi mphamvu yowonjezereka koma imatenga nthawi (masiku awiri mpaka atatu), ndipo imafuna malo apadera ndi antchito ophunzitsidwa bwino;

Poizoni A/B ELISA: Kuyesa kosavuta komanso kwachangu (maola 1-2) ndi mphamvu yochepa komanso nthawi zambiri zolakwika;

Mayeso a Kukulitsa kwa Nucleic Acid (NAATs): Yofulumira (maola 1-3) komanso yodziwika bwino komanso yeniyeni, kuzindikira majini omwe amachititsa kupanga poizoni;

Kuphatikiza apo, mayeso ojambulira kuti aone matumbo, mongaKujambula kwa CTndiX-ray, ingagwiritsidwenso ntchito pothandiza kupeza matenda a C. diff ndi mavuto a C. diff, monga matenda a m'matumbo.

Chithandizo cha matenda a C. Diff

Pali njira zambiri zochiritsira matenda a C. diff. Nazi njira zabwino kwambiri:

• Mankhwala opha tizilombo toyambitsa matenda monga vancomycin, metronidazole kapena fidaxomicin amagwiritsidwa ntchito kwambiri chifukwa mankhwalawa amatha kudutsa m'mimba ndikufikira m'matumbo momwe mabakiteriya a C. diff amakhala.
• Metronidazole yolowetsedwa m'mitsempha ingagwiritsidwe ntchito pochiza ngati matenda a C. diff ndi oopsa.
• Kusamutsa tizilombo toyambitsa matenda m'chimbudzi kwasonyeza kuti ndi kothandiza pochiza matenda opatsirana pafupipafupi a C. diff ndi matenda oopsa a C. diff omwe sayankha mankhwala opha majeremusi.
• Opaleshoni ingafunike pa milandu yoopsa.

Zatsopano dyankho la iagnostic kuchokera ku MMT

Pofuna kuthana ndi kufunika kozindikira mwachangu komanso molondola za C. difficile, tayambitsa Nucleic Acid Detection Kit yathu yatsopano yopezera poizoni wa Clostridium difficile wa jini la A/B, zomwe zimathandiza akatswiri azaumoyo kuti azitha kuzindikira matenda msanga komanso molondola komanso kuthandizira kulimbana ndi matenda omwe amabwera kuchipatala.

• Kuzindikira Kwambiri: Imazindikira mpaka200 CFU/mL,;
• Kulunjika Molondola: Amazindikira bwino lomwe C. zovutajini la poizoni A/B, kuchepetsa zabwino zabodza;
• Kuzindikira Mwachindunji Matenda Oyambitsa Matenda: Amagwiritsa ntchito mayeso a nucleic acid kuti adziwe mwachindunji majini a poizoni, ndikukhazikitsa muyezo wabwino kwambiri wodziwira matenda.
• Yogwirizana kwathunthu ndizida zazikulu za PCR zomwe zimayang'ana ma laboratories ambiri;

Yankho la Chitsanzo cha Mayankho latsegulidwaMacro & Micro-Test'sAIO800Labu ya PCR ya m'manja

Kukonza Zinthu Mwachitsanzo Kuti Muyankhe – Ikani machubu oyambira a zitsanzo (1.5–12 mL) mwachindunji, kuchotsa mapaipi opangidwa ndi manja. Kuchotsa, kukulitsa, ndi kuzindikira kumachitika zokha, zomwe zimachepetsa nthawi yogwira ntchito komanso zolakwa za anthu.

• Chitetezo cha Kuipitsidwa kwa Zigawo 11 - Kuyenda kwa mpweya molunjika, kupanikizika koipa, kusefa kwa HEPA, kuyeretsa UV, zochita zotsekedwa, ndi chitetezo china chophatikizidwa chimateteza antchito ndikuwonetsetsa zotsatira zodalirika panthawi yoyesa kwambiri.

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