Malinga ndi lipoti laposachedwa la khansa padziko lonse lapansi, khansa ya m'mapapo ikupitirira kukhala chifukwa chachikulu cha imfa zokhudzana ndi khansa padziko lonse lapansi, zomwe zimapangitsa kuti 18.7% ya imfa zonse zoterezi zichitike mu 2022. Ambiri mwa milanduyi ndi Non-Small Cell Lung Cancer (NSCLC). Ngakhale kuti kudalira mankhwala a chemotherapy m'mbuyomu pa matenda opitilira patsogolo sikunapereke phindu lalikulu, lingaliro lasintha kwambiri.
Kupezeka kwa zizindikiro zofunika kwambiri, monga EGFR, ALK, ndi ROS1, kwasintha njira yochizira, kuchoka pa njira imodzi yokwanira zonse kupita ku njira yolondola yomwe imayang'ana kwambiri majini apadera omwe amachititsa khansa ya wodwala aliyense.
Komabe, kupambana kwa njira zatsopanozi kumadalira kwathunthu kuyesa majini molondola komanso kodalirika kuti tidziwe cholinga choyenera cha wodwala woyenera.
Zizindikiro Zofunika Kwambiri za Biomarkers: EGFR, ALK, ROS1, ndi KRAS
Zizindikiro zinayi za biomarker zimayimira maziko a matenda a NSCLC, zomwe zikutsogolera zisankho zoyamba za chithandizo:
-EGFR:Kusintha kwa majini komwe kumadziwika kwambiri, makamaka kwa anthu aku Asia, akazi, komanso osasuta. Mankhwala oletsa tyrosine kinase (TKIs) a EGFR monga Osimertinib athandiza kwambiri odwala.
-ALK:"Kusintha kwa diamondi," kumapezeka mwa 5-8% ya milandu ya NSCLC. Odwala omwe ali ndi ALK fusion positive nthawi zambiri amayankha kwambiri ku ALK inhibitors, zomwe zimapangitsa kuti apulumuke kwa nthawi yayitali.
-ROS1:Pokhala ndi kufanana kwa kapangidwe kake ndi ALK, "mtengo wamtengo wapatali wosowa" uwu umapezeka mwa odwala 1-2% a NSCLC. Mankhwala othandiza omwe amaperekedwa amapezeka, zomwe zimapangitsa kuti kudziwika kwake kukhale kofunika kwambiri.
-KRAS:Kalekale, kusintha kwa KRAS komwe kumaonedwa kuti ndi "kosagwiritsidwa ntchito mankhwala," ndikofala. Kuvomerezedwa kwaposachedwa kwa zoletsa za KRAS G12C kwasintha chizindikiro ichi kuchokera ku chizindikiro cholosera kukhala cholinga chogwira ntchito, kusintha chisamaliro cha gulu la odwala awa.
Chikalata cha MMT: Chopangidwa kuti chikhale ndi chidaliro chozindikira matenda
Kuti akwaniritse kufunika kofunikira kozindikira bwino za biomarker, MMT imapereka mndandanda wa ma grafu a CE-IVD omwe amalembedwa nthawi yeniyeni.Zipangizo zodziwira PCR, chilichonse chinapangidwa ndi ukadaulo wapamwamba kwambiri kuti zitsimikizire kuti matenda ndi odalirika.
1. Kiti Yodziwira Kusintha kwa EGFR
-Ukadaulo Wowonjezera wa ARMS:Zowonjezera zaumwini zimawonjezera kukulitsa kwa kusintha kwa thupi.
-Kuwonjezeka kwa Enzymatic:Ma endonuclease oletsa kugaya maziko a genomic amtundu wachilengedwe, kukulitsa ma mutant sequences ndikuwonjezera resolution.
-Kuletsa Kutentha:Gawo lapadera la kutentha limachepetsa kutentha kosafunikira, zomwe zimachepetsanso maziko achilengedwe.
-Ubwino Waukulu:Kuzindikira kosayerekezeka mpaka1%ma frequency a allele osinthika, kulondola kwabwino kwambiri ndi zowongolera zamkati ndi enzyme ya UNG, komanso nthawi yofulumira yosinthira pafupifupiMphindi 120.
- Yogwirizana ndizitsanzo zonse za minofu ndi zamadzimadzi za biopsy.
- MMT EML4-ALK Fusion Detection Kit
- Kuzindikira Kwambiri:Amazindikira molondola kusintha kwa fusion ndi malire ochepa ozindikira makope 20/reaction.
-Kulondola Kwambiri:Imaphatikiza miyezo yamkati yowongolera njira ndi enzyme ya UNG kuti ipewe kuipitsidwa komwe kumapitirira, ndikupewa zabwino ndi zoyipa zabodza.
-Zosavuta & Zachangu:Ili ndi ntchito yophweka komanso yotsekedwa yomwe imatenga pafupifupi mphindi 120.
-Kugwirizana kwa Chida:Yosinthika ku mitundu yosiyanasiyana ya zinthuzida za PCR zenizeni, zomwe zimapangitsa kuti zikhale zosavuta kugwiritsa ntchito mu labotale iliyonse.
- Chida Chodziwira Fusion cha MMT ROS1
Kuzindikira Kwambiri:Imasonyeza magwiridwe antchito abwino kwambiri mwa kuzindikira molondola mpaka makope 20/machitidwe a zolinga zosakanikirana.
Kulondola Kwambiri:Kugwiritsa ntchito njira zowongolera khalidwe la mkati ndi enzyme ya UNG kumatsimikizira kudalirika kwa zotsatira zilizonse, kuchepetsa chiopsezo cha malipoti olakwika.
Zosavuta & Zachangu:Monga makina otsekedwa, safuna njira zovuta zowonjezerera mphamvu pambuyo pa kukulitsa. Zotsatira zenizeni komanso zodalirika zimapezeka mu mphindi pafupifupi 120.
Kugwirizana kwa Chida:Yapangidwa kuti igwirizane kwambiri ndi makina ambiri a PCR, zomwe zimathandiza kuti ikhale yosavuta kuphatikiza mu ntchito zomwe zilipo kale za labu.
- MMT KRAS Kusintha kwa Masinthidwe
- Ukadaulo wa ARMS wowonjezereka, wolimbikitsidwa ndi Enzymatic Enrichment ndi Temperature Blocking.
- Kuwonjezeka kwa Enzymatic:Amagwiritsa ntchito ma endonuclease oletsa kugaya bwino maziko a genomic a mtundu wachilengedwe, motero amawonjezera ma mutant sequences ndikuwonjezera kwambiri kuzindikira.
-Kuletsa Kutentha:Zimakhazikitsa gawo la kutentha komwe kumayambitsa kusagwirizana pakati pa ma primer enieni a mutant ndi ma tempuleti amtundu wa wild, zomwe zimachepetsa maziko ndikuwonjezera kudziwika.
- Kuzindikira Kwambiri:Imapeza mphamvu yozindikira ya 1% ya ma mutant alleles, kuonetsetsa kuti pali ma mutants ochepa.
-Kulondola Kwambiri:Miyezo yolumikizidwa mkati ndi enzyme ya UNG zimateteza ku zotsatira zabodza zabwino ndi zoyipa.
-Gulu Lonse:Yokonzedwa bwino kuti ithandize kuzindikira masinthidwe asanu ndi atatu a KRAS m'machubu awiri okha a reaction.
- Zosavuta & Zachangu:Imapereka zotsatira zenizeni komanso zodalirika mu mphindi pafupifupi 120.
- Kugwirizana kwa Chida:Imasintha mosavuta ku zida zosiyanasiyana za PCR, zomwe zimapangitsa kuti zikhale zosiyanasiyana m'ma laboratories azachipatala.
Chifukwa Chiyani Sankhani Njira ya MMT NSCLC?
Zonse: Chida chokwanira cha ma biomarker anayi ofunikira kwambiri a NSCLC.
Zapamwamba paukadaulo: Zowonjezera za umwini (Kuwonjezera Enzymatic, Kuletsa Kutentha) zimatsimikizira kutsimikizika kwakukulu komanso kukhudzidwa komwe kuli kofunikira kwambiri.
Mwachangu & Mwachangu: Njira yofanana ya mphindi 120 pagawo lonse la ntchito imafulumizitsa nthawi yokonzekera chithandizo.
Yosinthasintha & Yopezeka: Imagwirizana ndi mitundu yosiyanasiyana ya zitsanzo ndi zida zazikulu za PCR, kuchepetsa zopinga zogwiritsira ntchito.
Mapeto
Mu nthawi ya matenda olondola a khansa, kuzindikira mamolekyulu ndi njira yothandiza poyang'anira njira zochiritsira. Zida zapamwamba zodziwira matenda za MMT zimapatsa mphamvu madokotala kuti azitha kujambula molimba mtima momwe majini a NSCLC ya wodwala amaonekera, ndikutsegula njira zopulumutsira moyo zomwe zimagwiritsidwa ntchito pochiza matenda.
Contact to learn more: marketing@mmtest.com
Nthawi yotumizira: Novembala-05-2025