Malinga ndi lipoti laposachedwa la khansa yapadziko lonse lapansi, khansa ya m'mapapo ikupitirizabe kukhala yomwe imayambitsa imfa zokhudzana ndi khansa padziko lonse lapansi, zomwe zimapanga 18.7% mwa anthu omwe amafa mu 2022. Ambiri mwa milanduyi ndi Non-Small Cell Lung Cancer (NSCLC). Ngakhale kudalira chemotherapy kwa matenda apamwamba kumapereka phindu lochepa, paradigm yasintha kwambiri.
Kupezeka kwa ma biomarkers ofunikira, monga EGFR, ALK, ndi ROS1, kwasintha chithandizo, ndikuchichotsa panjira yofanana ndi njira yolondola yomwe imayang'ana madalaivala apadera a khansa ya wodwala aliyense.
Komabe, kupambana kwa chithandizo chakusintha kumeneku kumadalira kwambiri kuyesa kolondola ndi kodalirika kwa majini kuti azindikire chandamale choyenera cha wodwala woyenera.
The Critical Biomarkers: EGFR, ALK, ROS1, ndi KRAS
Ma biomarkers anayi amaima ngati mizati pakuzindikiritsa kwa mamolekyu a NSCLC, kuwongolera zisankho zachipatala choyamba:
-EGFR:Kusintha kofala kwambiri, makamaka ku Asia, akazi, komanso osasuta. EGFR tyrosine kinase inhibitors (TKIs) monga Osimertinib yasintha kwambiri zotsatira za odwala.
-ALK:"Kusintha kwa diamondi," komwe kulipo mu 5-8% yamilandu ya NSCLC. Odwala omwe ali ndi ALK fusion-positive nthawi zambiri amayankha mozama kwa ALK inhibitors, kuti apulumuke kwa nthawi yaitali.
-ROS1:Kugawana zofanana zamapangidwe ndi ALK, "mwala wosowa" uwu umapezeka mu 1-2% ya odwala a NSCLC. Njira zochiritsira zogwira mtima zilipo, zomwe zimapangitsa kuzindikira kwake kukhala kofunikira.
-KRAS:M'mbiri yakale, zosinthika za KRAS ndizofala. Chivomerezo chaposachedwa cha KRAS G12C inhibitors chasintha chizindikiro ichi kukhala cholozera kukhala chandamale chotheka kuchita, kusinthira chisamaliro cha odwalawa.
MMT Portfolio: Yopangidwira Diagnostic Confidence
Kukwaniritsa chosowa chachangu cha chizindikiritso cholondola cha biomarker, MMT imapereka mbiri ya CE-IVD yolembedwa nthawi yeniyeni.Zida zodziwira PCR, chilichonse chopangidwa ndiukadaulo wapamwamba kwambiri kuti chitsimikizire chidaliro cha matenda.
1. EGFR Mutation Detection Kit
-Tekinoloje Yowonjezera ya ARMS:Zowonjezera zowonjezera zimawonjezera kukulitsa kwachindunji.
-Kuchulukitsa kwa Enzymatic:Restriction endonucleases amagaya maziko amtundu wakuthengo, kukulitsa kutsatizana kosinthika komanso kukulitsa kusamvana.
-Kuletsa Kutentha:Kutentha kwapadera kumachepetsa priming yomwe siinatchulidwe, ndikuchepetsanso zakutchire.
-Ubwino waukulu:Kukhudzika kosagwirizana mpaka1%mutant allele frequency, kulondola kwambiri ndi zowongolera zamkati ndi UNG enzyme, komanso nthawi yosinthira mwachangu pafupifupiMphindi 120.
- Yogwirizana ndizitsanzo zonse za minofu ndi madzi a biopsy.
- MMT EML4-ALK Fusion Detection Kit
- Kumverera Kwambiri:Imazindikira molondola masinthidwe ophatikizika ndi malire otsika ozindikira makope a 20 / zochita.
-Kulondola Kwambiri:Imaphatikizanso miyezo yamkati yowongolera njira ndi UNG enzyme kuti mupewe kuipitsidwa kwa carryover, popewa kupewa zabwino ndi zoyipa zabodza.
-Zosavuta & Zofulumira:Imakhala ndi ntchito yosinthika, yotsekedwa yomalizidwa pafupifupi mphindi 120.
-Kugwirizana kwa Chida:Zosinthika zosiyanasiyana wambazida zenizeni za PCR, kupereka kusinthasintha pakukhazikitsa kwa labotale kulikonse.
- MMT ROS1 Fusion Detection Kit
Kumverera Kwambiri:Imawonetsa kuchita bwino kwambiri pozindikira modalirika makope 20/zochita za mikangano yosakanikirana.
Kulondola Kwambiri:Kugwiritsa ntchito zowongolera zamkati zamkati ndi enzyme ya UNG kumatsimikizira kudalirika kwa zotsatira zilizonse, kuchepetsa chiopsezo chofotokozera zolakwika.
Zosavuta & Zofulumira:Monga kachitidwe ka chubu chotsekedwa, sichifuna njira zovuta zowonjezeretsa. Zolinga ndi zodalirika zimapezedwa pafupifupi mphindi 120.
Kugwirizana kwa Chida:Zapangidwira kuti zigwirizane ndi makina osiyanasiyana a PCR, zomwe zimathandizira kuphatikizana kosavuta ndikuyenda kwa labu.
- MMT KRAS Mutation Detection Kit
- Ukadaulo wolimbikitsidwa wa ARMS, wolimbikitsidwa ndi Enzymatic Enrichment and Temperature blocking.
- Kuchulukitsa kwa Enzymatic:Imagwiritsa ntchito ma endonucleases oletsa kugaya maziko amtundu wakuthengo, potero kumawonjezera kutsata kosinthika komanso kupititsa patsogolo kuzindikira.
-Kuletsa Kutentha:Imayambitsa sitepe yapadera ya kutentha kuti ipangitse kusagwirizana pakati pa zoyambira zenizeni ndi ma tempuleti akutchire, kumachepetsanso maziko ndikusintha mawonekedwe ake.
- Kumverera Kwambiri:Imakwaniritsa kukhudzika kwa 1% kwa ma mutant alleles, kuwonetsetsa kuzindikirika kwa masinthidwe otsika kwambiri.
-Kulondola Kwambiri:Miyezo yamkati yophatikizika ndi ma enzyme a UNG amateteza ku zotsatira zabodza komanso zoyipa.
-Gulu Lonse:Zokonzedwa bwino kuti zithandizire kuzindikira masinthidwe asanu ndi atatu a KRAS pamachubu awiri okha.
- Zosavuta & Zofulumira:Amapereka zotsatira zodalirika komanso zodalirika pafupifupi mphindi 120.
- Kugwirizana kwa Chida:Imasinthasintha mosasunthika ku zida zosiyanasiyana za PCR, zomwe zimapereka kusinthasintha kwama laboratories azachipatala.
Chifukwa Chiyani Sankhani MMT NSCLC Solution?
Zokwanira: Gulu lathunthu lazinthu zinayi zofunika kwambiri za NSCLC biomarkers.
Zaukadaulo Zapamwamba: Zowonjezera Zaumwini (Kulemeretsa kwa Enzymatic, Kutsekereza Kutentha) zimatsimikizira kutsimikizika kwakukulu komanso kukhudzika komwe kuli kofunikira kwambiri.
Mwachangu & Mwachangu: Uniform ~ 120-mphindi protocol kudutsa mbiri imathandizira nthawi yolandira chithandizo.
Zosinthika & Zopezeka: Zimagwirizana ndi mitundu yambiri ya zitsanzo ndi zida za PCR, kuchepetsa zolepheretsa kukhazikitsa.
Mapeto
M'nthawi ya oncology yolondola, kuyezetsa kwa ma cell ndi kampasi yomwe imatsogolera njira zochiritsira. Zida zodziwira zapamwamba za MMT zimapereka mphamvu kwa asing'anga kuti azitha kujambula molimba mtima mawonekedwe amtundu wa NSCLC ya wodwala, ndikutsegula mwayi wopulumutsa moyo wa machiritso omwe akuwunikiridwa.
Contact to learn more: marketing@mmtest.com
Nthawi yotumiza: Nov-05-2025