Ndemanga yaClassic Research Paper
Respiratory Syncytial Virus (RSV) ndi Human Metapneumovirus (HMPV) ndi t.matenda ogwirizana kwambiri mkati mwaPneumoviridaebanjaamene nthawi zambiri amasokonezeka pa ana pachimake kupuma matenda. Pomwe mawonekedwe awo azachipatala amapitilira, zomwe zikuyembekezeka (2016-2020) kuchokera kuzipatala za ana 7 zaku US - kuphatikiza odwala 8,605 - zimawulula kusiyana kwakukulu kwa anthu omwe ali pachiwopsezo chachikulu, kuopsa kwa matenda, komanso kasamalidwe kachipatala. Kafukufukuyu adagwiritsa ntchito njira yolimbikitsira, yoyembekezeredwa yosonkhanitsidwa mwadongosolo komanso kuyesa ma virus 8 opumira, zomwe zimapereka kufananitsa koyamba kwakukulu, kwenikweni kwapadziko lonse kwa madokotala a ana. Pakuwunika kuchuluka kwa anthu ogonekedwa m'chipatala, kugonekedwa kwa ICU, kugwiritsa ntchito mpweya wabwino, komanso kukhala m'chipatala nthawi yayitali (≥3 masiku), kumakhazikitsa maziko ofunikira asanayambe kulowererapo pa nthawi ya katemera wa RSV watsopano (mwachitsanzo, katemera wa amayi, chitetezo cham'thupi chanthawi yayitali) ndikupanga dongosolo lachitukuko la HMPV mtsogolo.
Kupeza Mfungulo 1: Mbiri Zachiwopsezo Chambiri
-RSV imakhudza makamaka makanda:Zaka zapakati zogonekedwa m'chipatala zinali miyezi 7 yokha, pomwe 29.2% ya odwala omwe adavomerezedwa amakhala akhanda (miyezi 0-2). RSV ndiyomwe imayambitsa kugonekedwa m'chipatala kwa makanda osakwana miyezi 6, ndipo kuuma kwake kumayenderana ndi zaka.
-HMPV imayang'ana ana okulirapo komanso omwe ali ndi zovuta zina:Zaka zapakati zogonekedwa m'chipatala zinali miyezi 16, zomwe zimakhudza kwambiri ana opitilira chaka chimodzi. Mwachidziwitso, kufalikira kwa zovuta zachipatala (mwachitsanzo, mtima, mitsempha, kupuma) zinali zochulukirapo kuposa odwala a HMPV (26%) poyerekeza ndi odwala a RSV (11%), kuwonetsa chiopsezo chawo chowonjezereka.
Chithunzi 1. Kugawidwa kwa zaka za maulendo a ED ndi zipatalakugwirizana ndi RSV kapena HMPV
mwa ana osakwana zaka 18.
Kupeza Mfungulo 2: Kusiyanitsa Zowonetsa Zachipatala
-RSV imawonekera ndi zizindikiro zodziwika bwino za kupuma:Zimagwirizanitsidwa kwambiri ndi bronchiolitis (76.7% ya milandu yachipatala). Zizindikiro zazikulu zikuphatikizapokuchotsedwa kwa khoma pachifuwa (76.9% odwala odwala; 27.5% ED)nditachypnea (odwala 91.8%; 69.8% ED), onse pafupipafupi kwambiri kuposa mu HMPV.
-HMPV imakhala ndi chiwopsezo chachikulu cha kutentha thupi komanso chibayo:Chibayo chinapezeka mu 35.6% ya odwala HMPV omwe ali m'chipatala-kuwirikiza kawiri mlingo wa RSV.Kutentha kwa thupi kunali kofala kwambiri (83.6% odwala odwala; 81% ED). Ngakhale zizindikiro za kupuma monga kupuma ndi tachypnea zimachitika, nthawi zambiri zimakhala zochepa kwambiri kuposa za RSV.
Chithunzi 2.Kufananiza makhalidwe ndi matendaIndeya RSV motsutsana ndi HMPV mwa ana ochepera zaka 18.
Chidule: RSVAmayambitsa matenda oopsa mwa ana aang'ono, omwe amadziwika ndi kupuma kwakukulu (kupuma, kupuma) ndi bronchiolitis.Zithunzi za HMPVnthawi zambiri amakhudza ana okulirapo omwe ali ndi matenda ena, omwe amakhala ndi malungo, amakhala pachiwopsezo chachikulu cha chibayo, ndipo nthawi zambiri amayambitsa kutupa.
Kupeza Mfungulo 3: Zitsanzo za Nyengo Zofunika
-RSV ili ndi pachimake choyambirira, chodziwikiratu:Zochita zake zimakhazikika kwambiri, nthawi zambiri zimakhazikika pakatiNovember ndi January, zomwe zimapangitsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda kwa makanda m'dzinja ndi m'nyengo yozizira.
-HMPV ifika pachimake pambuyo pake ndikusinthasintha kwakukulu:Nthawi yake imafika mochedwa, nthawi zambiri imafika pachimakeMarch ndi April, ndikuwonetsa kusintha kwakukulu kwa chaka ndi chaka ndi madera, nthawi zambiri kumawoneka ngati "mafunde achiwiri" pambuyo pa kuchepa kwa RSV.
Chithunzi 3.Ponseponse komanso patsamba la PCR positivemitengo ya RSV ndi HMPV pakati pa ana osakwana zaka 18 omwe ali ndi matenda aacute kupuma (ARI) -okhudzana ndi maulendo a ED ndi kukagonekedwa kuchipatala.
Kupewa ndi Kusamalira: Dongosolo Lotengera Umboni
-RSV Prophylaxis:Njira zopewera zilipo tsopano. Mu 2023, US FDA idavomereza anti-monoclonal antibody (Nirsevimab), yomwe imatha kuteteza makanda kwa miyezi isanu yoyamba. Kuphatikiza apo, katemera wa RSV wa amayi amasamutsa ma antibodies oteteza kwa ana obadwa kumene.
-HMPV Prophylaxis:Panopa palibe mankhwala ovomerezeka oletsa. Komabe, olandila katemera angapo (mwachitsanzo, katemera wa AstraZeneca wa RSV/HMPV) ali m'mayesero azachipatala. Makolo akulangizidwa kuti azidziwitsidwa zosintha kuchokera kwa akuluakulu azaumoyo.
Fufuzani Chisamaliro Chamankhwala Mwamsanga pa ILIYONSE mwa “Red Flags” Izi:
-Kutentha kwa makanda:Kutentha ≥38°C (100.4°F) mwa khanda lililonse lochepera miyezi itatu yakubadwa.
-Kukwera Kopumira:Kupuma kumaposa mpweya wa 60 pamphindi kwa makanda 1-5 miyezi, kapena mpweya wa 40 pamphindi kwa ana a zaka 1-5, zomwe zimasonyeza kuvutika kwa kupuma.
-Kuchuluka kwa Oxygen:Oxygen saturation (SpO₂) imagwera pansi pa 90%, chizindikiro chovuta cha matenda aakulu omwe amawonedwa mu 30% ya RSV ndi 32.1% ya milandu yachipatala ya HMPV mu phunziroli.
-Zovuta za Lethargy kapena Kudyetsa:Kutopa kodziwikiratu kapena kuchepa kwa madyedwe amkaka ndi gawo limodzi mwa magawo atatu mkati mwa maola 24, zomwe zitha kukhala kalambula bwalo wakusowa madzi m'thupi.
Ngakhale kuti ndizosiyana mu miliri ndi zochitika zachipatala, kusiyanitsa molondola pakati pa RSV ndi HMPV panthawi ya chisamaliro kumakhalabe kovuta. Kuphatikiza apo, chiwopsezo chachipatala chimapitilira ma virus awiriwa, okhala ndi tizilombo toyambitsa matenda monga fuluwenza A ndi mitundu ina ya tizilombo toyambitsa matenda komanso mabakiteriya omwe akuwopseza thanzi la anthu nthawi imodzi. Kuzindikira kwanthawi yake komanso kulondola kwa etiological ndikofunikira kuti pakhale chithandizo choyenera, kudzipatula koyenera, komanso kugawa bwino zinthu.
Kuyambitsa AIO800 + 14-Pathogen Combined Detection Kit (Fluorescence PCR)(NMPA, CE, FDA, SFDA yovomerezeka)
Kuti akwaniritse zofunazi, aEudemon™ AIO800 Fully Automatic Nucleic Acid Detection System, kuphatikiza ndi a14-pathogen kupuma gulu, imapereka njira yosinthira - kupereka zoona"chitsanzo, yankhani"matenda m'mphindi 30 zokha.
Mayeso athunthu a kupuma awa azindikirema virus ndi mabakiteriyakuchokera ku chitsanzo chimodzi, zomwe zimathandiza opereka chithandizo chamankhwala kutsogolo kuti apange zisankho zodalirika, panthawi yake, komanso zomwe akulimbana nazo.
Zofunika Kwambiri Pamakina Ofunika kwa Makasitomala Anu
Fully Automated Workflow
Pasanathe mphindi 5 manja pa nthawi. Palibe chifukwa cha akatswiri ogwira ntchito zama cell.
- Zotsatira Zachangu
Nthawi yosinthira ya mphindi 30 imathandizira zochitika zachipatala mwachangu.
- 14Kuzindikira kwa Pathogen Multiplex
Kuzindikiritsa munthawi yomweyo:
Ma virus:COVID-19,Influenza A & B,RSV,Adv,hMPV,Rhv,Parainfluenza mitundu I-IV,HBoV,EV,CoV
Bakiteriya:MP,Cpn, SP
-Lyophilized Reagents Okhazikika Pakutentha kwa Chipinda (2–30°C)
Imasavuta kusungirako ndi mayendedwe, ndikuchotsa kudalira kozizira.
Dongosolo Lamphamvu Loletsa Kuyipitsidwa
11-wosanjikiza zoletsa kuipitsidwa kuphatikiza kutsekereza kwa UV, kusefera kwa HEPA, ndi kayendedwe ka katiriji kotseka, ndi zina zambiri.
Kuzindikiritsa mofulumirirapo, kokwanira kwa tizilombo toyambitsa matenda ndiko maziko a kasamalidwe kamakono ka matenda a kupuma kwa ana. Dongosolo la AIO800, lomwe lili ndi makina ake odzichitira okha, mphindi 30, multiplex PCR, limapereka yankho lothandiza pamakonzedwe apatsogolo. Pothandizira kuzindikira koyambirira komanso kolondola kwa RSV, HMPV, ndi tizilombo toyambitsa matenda, imapatsa mphamvu asing'anga kupanga zisankho zomwe akufuna, kukhathamiritsa kugwiritsa ntchito maantibayotiki, ndikukhazikitsa njira zowongolera matenda - pamapeto pake kupititsa patsogolo chisamaliro cha odwala komanso chisamaliro chaumoyo.
#RSV #HMPV #Mwachangu #Chidziwitso #Zopumira #Pathogen # Zitsanzo-Kuyankha#MacroMicroTest
Nthawi yotumiza: Dec-02-2025