Mavuto Owonjezereka a Kukana Mankhwala Opha Majeremusi
Kukwera mofulumira kwa kukana maantibayotiki (AMR) ndi chimodzi mwa mavuto akuluakulu padziko lonse lapansi pa thanzi lathu. Bungwe la World Health Organization lalemba MRSA ngati matenda oyamba. Pakati pa tizilombo toyambitsa matenda tosagonjetsedwa, Staphylococcus aureus (MRSA) yosagonjetsedwa ndi methicillin ndi yodetsa nkhawa kwambiri. Malinga ndi kafukufuku wa Global Burden of Disease wofalitsidwa mu The Lancet (2024), imfa zomwe zimayambitsidwa ndi MRSA zinawonjezeka kuchoka pa 57,200 mu 1990 kufika pa 130,000 mu 2021 - kuwonjezeka kopitilira kawiri pazaka makumi atatu [1]. Kafukufukuyu akuwonetsanso kuti pofika chaka cha 2050, anthu pafupifupi 40 miliyoni akhoza kutaya miyoyo yawo chifukwa cha matenda opatsirana ndi tizilombo toyambitsa matenda tosagonjetsedwa ndi maantibayotiki. MRSA imabweretsa kukhala m'chipatala kwa nthawi yayitali, ndalama zowonjezera zachipatala, komanso imfa zambiri, makamaka pakati pa odwala odwala kwambiri, odwala opaleshoni, ndi okhala m'chipatala cha nthawi yayitali.
KumvetsetsaStaphylococcus aureusndi MRSA
Staphylococcus aureus (SA) ndi chifukwa chachikulu cha matenda okhudzana ndi thanzi. Ndi coccus ya Gram positive yomwe imapanga poizoni osiyanasiyana ndi ma enzyme olowa m'thupi, ndipo imadziwika chifukwa chakufalikira kwakukulu, matenda amphamvu, komanso kukana kwambiriJini la nuclease lotenthetsera (nuc) ndi chandamale chosungidwa bwino kwambiri kuti chizindikirike ndi SA.
MRSA ikhoza kugawidwa m'magulu atatu kutengera komwe idachokera:
-MRSA Yogwirizana ndi Zaumoyo (HA MRSA)- makamaka amapezeka m'zipatala ndi m'malo osamalira odwala kwa nthawi yayitali
-MRSA yogwirizana ndi anthu ammudzi (CA MRSA)- zimachitika kunja kwa malo azaumoyo
-MRSA Yogwirizana ndi Ziweto (LA MRSA)
Njira Zopezera Matenda ndi Zotsatira Zachipatala za MRSA
MRSA ikhoza kulowa m'thupi kudzera mumabala a pakhungu, ma follicle a tsitsi, kapena magazi, zomwe zimayambitsa matenda opatsirana. Odwala matenda a pakhungu kapena kupsa amakhala pachiwopsezo chachikulu cha matenda a MRSA. Chibayo ndi chimodzi mwa zizindikiro zofala kwambiri za matenda a MRSA, ndipo chithandizo chosayenera ndi chomwe chimayambitsa imfa zambiri. Chifukwa chake, kuzindikira ndi kuchiza chibayo cha MRSA kumakumana ndi mavuto akulu ndipo kumafunika chisamaliro chapadera.
Chinsinsi cha Kupewa ndi Kuletsa Matenda: Kuwunika Mosakhalitsa
Odwala omwe ali m'chipatala - kuphatikizapo omwe ali m'zipinda zosamalira odwala kwambiri, m'zipinda zochitira opaleshoni, komanso m'malo osamalira odwala kwa nthawi yayitali - ali pachiwopsezo chachikulu cha matenda a MRSA. Kuzindikira msanga matenda a MRSA ndikofunikira kwambiri popewa kufalikira kwa matenda m'zipatala, kugwiritsa ntchito njira zodzitetezera, komanso kuchepetsa matenda opatsirana.
Njira zochizira matenda nthawi zambiri zimatenga maola 48-72 kuti zipereke zotsatira. Panthawi imeneyi, anthu onyamula MRSA akhoza kukhala magwero ofala. Kuyesa mwachangu kwa mamolekyulu kumafupikitsa nthawi yowunikira, zomwe zimathandiza kuzindikira msanga, kudzipatula msanga, komanso kuchitapo kanthu msanga.
SA & MRSAKuzindikira kuchokera ku Macro ndi Micro-Test
Cholinga chake ndi kuzindikira nucleic acids kuchokera ku Staphylococcus aureus ndi Staphylococcus aureus yokana methicillin m'zitsanzo za sputum za anthu, zitsanzo za swab ya m'mphuno, ndi zitsanzo za matenda a pakhungu ndi minofu yofewa. Ntchito zake ndi izi:
-Kupewa ndi kuwongolera matenda m'malo azaumoyo- kwa odwala omwe ali m'chipatala, kuphatikizapo odwala odwala kwambiri, odwala opaleshoni, ndi odwala omwe ali ndi chithandizo cha nthawi yayitali
-Kuzindikira matenda opatsirana popuma- kwa odwala omwe akuganiziridwa kuti ali ndi matenda opatsirana popuma a SA kapena MRSA
-Kuzindikira matenda a pakhungu ndi minofu yofewa- mogwirizana ndi mayeso ena a labotale monga kukulitsa tizilombo toyambitsa matenda
Yankho Loyesera Kwambiri: AIO800+ SA & MRSA Dongosolo Lodziyimira Lokha la POCT
Macro & Micro-Test's AIO800 POCT yodziyimira yokha komanso zida zodziwira matenda za SA & MRSA, chida chothandiza kwambiri popewera ndi kuwongolera matenda m'zipatala.
-Mitundu yambiri ya zitsanzo- Zitsanzo za makoswe, zopopera m'mphuno, matenda a pakhungu ndi minofu yofewa
-Kayendedwe ka ntchito kokhazikika- Kutumiza mwachindunji kuchokera ku machubu oyambira a zitsanzo (1.5mL–12mL); kugwiritsa ntchito nthawi yochepa, kuchepetsa zolakwika za anthu
-Kuzindikira kwambiri- Malire ozindikira omwe ndi otsika ngati 1000 CFU/mL kwa onse SA ndi MRSA
-Zotsatira zachangu- Mwachangu kwambiri kuposa chikhalidwe chachikhalidwe, zomwe zimathandiza kupewa matenda msanga
-Mafomu awiri a reagent- Zosankha zamadzimadzi ndi lyophilized zimathetsa mavuto osungira ndi mayendedwe
-Kuwongolera kuipitsidwa komwe kumangidwa mkati- Dongosolo loteteza la zigawo 11 (UV, HEPA filtration, paraffin sealing, etc.)
-Kugwirizana kwapadziko lonse- Imagwira ntchito ndi AIO800 ndi machitidwe akuluakulu a PCR
Zolinga ndi Kutanthauzira Zotsatira
Chida ichi chimazindikira zolinga ziwiri:
-nucjini: jini yosungidwa bwino komanso yeniyeni ya Staphylococcus aureus
-mecAjini: jini lofunika kwambiri lomwe limalimbana ndi kukana kwa methicillin
Kutanthauzira Zotsatira
-SA yoipa - Palibe Staphylococcus aureus yomwe yapezeka
-SA yabwino, MRSA yopanda bwino– S. aureus yapezeka, jini ya mecA sinapezeke
-SA positive, MRSA positive- S. aureus (MRSA) yosagonjetsedwa ndi Methicillin yapezeka
Zotsatirapo za Chisamaliro cha Odwala ndi Thanzi la Anthu Onse
Kugwiritsa ntchito mayeso ofulumira a mamolekyu kumapereka zabwino zazikulu:
-Kuwongolera bwino matenda- kuzindikira mwachangu anthu omwe ali ndi MRSA kumathandiza kudzipatula nthawi yake komanso kuchepetsa kufalikira kwa matenda m'chipatala.
-Zotsatira zabwino za chithandizo- Chidziwitso choyambirira cha matenda chimathandiza kupanga zisankho zachipatala
-Kuyang'anira matenda- Kuzindikira mwachangu kwa MRSA, pamodzi ndi chidziwitso chachipatala cha wodwala, kumapereka chidziwitso choyambirira cha komwe HA MRSA kapena CA MRSA idachokera, kuthandizira kuyang'anira matenda m'chipatala.
-Chithandizo cha kuyang'anira maantibayotiki- Kutsimikizira kapena kuchotsa MRSA koyambirira kumathandiza kuchepetsa kugwiritsa ntchito mankhwala opha tizilombo toyambitsa matenda mosayenera (nthawi zonse mogwirizana ndi chigamulo chachipatala)
Kuthana ndi vuto la MRSA kumafuna njira yogwirizana yomwe imaphatikiza ukadaulo wapamwamba wowunikira ndi njira zoyambira zowongolera matenda.Zipangizo zoyezera mwachangu, njira zodzipatula, kugwiritsa ntchito mankhwala opha tizilombo moyenera, komanso kuyang'anira nthawi zonsendi njira zodziwika bwino zowongolera MRSA m'malo azaumoyo.
Kodi mwakonzeka kusintha mayeso a SA ndi MRSA pogwiritsa ntchito chitsanzo chenicheni kuti muyankhe bwino?
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Onerani AIO800 ikugwira ntchito:
Zolemba:
[1] Ogwira Ntchito Olimbana ndi Matenda Padziko Lonse 2021 Olimbana ndi Mabakiteriya. (2024). Kulemera kwapadziko lonse kwa kukana kwa mabakiteriya oletsa mabakiteriya 1990–2021: kusanthula mwadongosolo ndi zolosera za 2050. The Lancet.
Nthawi yotumizira: Epulo-10-2026