Chida chatsopano cha matenda a chifuwa chachikulu ndi kukana mankhwala osokoneza bongo: M'badwo watsopano womwe umayang'ana zingwe (maenje) ophatikizidwa ndi maphunziro a Makina a chifuwa chachikulu matenda matenda a hypculosis
Lipoti la Mabuku: CCA: Mtundu wodziwika bwino malinga ndi ma denga ndi kuphunzira makina, zomwe ndizoyenera kwa anthu omwe ali ndi bakiteriya yaying'ono ya bakiteriya komanso meningitis.
Mutu wa Tsis: Kuphunzira kwamakina osindikizira: Njira yodziwikiratu ya matenda am'mimba pa pulpucy ndi meningitis ya tubular.
Nthawi zina: "Dodica Chiya Acta"
Ngati: 6.5
Tsiku la buku: Januware 2024
Anaphatikizidwa ndi Yunivesite ya China Academy of Sayansi ndi Chipatala cha Chipatala cha Macrucy Akuluakulu, Macro kuzindikira kwa chifuwa chachikulu chokhala ndi mabakiteriya komanso meningitis ochepa, adapereka njira yatsopano ya hypernansitititivity ya matenda awiri Mitundu ya chifuwa chachikulu, ndipo anathandiza kuti adziwe matendawa, kupezeka kwa mankhwala osokoneza bongo ndi chithandizo cha chifuwa chachikulu. Nthawi yomweyo, zimapezeka kuti plasma cfdna imatha kugwiritsidwa ntchito ngati mtundu woyenera wa matenda a TBM.
Pa phunziroli, zitsanzo za m'ma 227 zamasamba 227 zimagwiritsidwa ntchito kukhazikitsa makondo awiri azachipatala, pomwe zitsanzo za labotastic zidagwiritsidwa ntchito kukhazikitsa makina a chifuwa, Solution Model. Zitsanzo zonse zinakhazikitsidwa koyamba ndi dziwe lopangidwa mwapadera la perbe ya Mycobacacterium. Kenako, kutengera deta ya TB-TESS, mtundu wa mtengo wa Mtengo umagwiritsidwa ntchito popanga ma 5-phonye meding ya labotale, ndipo njira zodziwikiratu za zitsanzo za plasma ndi zitsanzo zamasamba zimapezeka. Cholinga chomwe chidzachitike chimachitika m'magawo awiri azachipatala kuti azindikire, ndipo matendawa amazindikira kuti wophunzirayo amawunikiridwa ndi Roc Curve. Pomaliza, matenda a chifuwa cha chifuwa chachikulu adapezeka.
Mkuyu. 1 chithunzi chojambula cha kapangidwe kake kafukufuku
Zotsatira: Malinga ndi njira yachidule ya CSF DNA Sample (Auc = 0.974) ndi Plasma Cfdna Sampuli (AUC = 20008) anali 95.6%, ndipo Kumverera kwachitsanzo kwa plasma kunali 82.61% ndi 86.36%. Powunikira zitsanzo za 44 za PFSMA CFDNA NDI STROSPININ DZIKO LAPANSI, njira yodziwiratu kafukufukuyu ali ndi ma plbrospel a dfdna ndi 95.45% (42/44). Mwa ana omwe ali ndi chifuwa chachikulu cha m'mapapo, njira yodziwiratu kafukufukuyu amakhudzidwa ndi zitsanzo za plasma kuposa zotsatira zam'madzi am'mimba kuchokera kwa omwe ali ndi zaka 15.38%).
Mkuyu. 2 Kusanthula Kugwiritsa kwa chifuwa cha chifuwa chachikulu cha kuchuluka kwa zitsanzo za anthu
Mkuyu. 3 zotsatira za zitsanzo za zitsanzo zapamwamba
Pomaliza: Njira yodziwitsa ya chifuwa chachikulu idakhazikitsidwa mu kafukufukuyu, zomwe zimatha kupereka chida chofufuzira kwambiri ndi chizindikiritso chachikulu kwambiri cha odwala matenda omwe ali ndi odwala matenda a a oligoboculosis (chikhalidwe chosasangalatsa). Kuzindikira chifuwa cha hyperclitititive cfmalna kungakhale mtundu woyenera pozindikira chifuwa chachikulu komanso ma mezanitis a chifuwa (ma plasma amasavuta kutolera madzi ampinculosis).
Ulalo woyambirira: https://www.CountDintchirect.com/sclunce/piic Ciicle/Pii/s00098123004991991019901990 kudzera% 3dihub
Kuyambitsa mwachidule za macro & micro-terdo-terncum
Poona zitsanzo zovuta za chifuwa chachikulu ndi zosowa zosiyanasiyana, mayeso a Macro & Micro-micro amapereka njira zonse zamagetsi, zomanga library ya library, ndi kusanthula kwa deta. Zogulitsa zimayambira matenda a chifuwa chachikulu, kupezeka kwa mankhwala osokoneza bongo, kuwunika kwa matenda a Mycobacterium ndi matenda a bacteria - anthu osokoneza bongo, etc.
Kuzindikira kwa SerICCulosis ndi Mycobacteria:
| Chinthu ayi | Dzina lazogulitsa | Zoyeserera Zogulitsa | Mtundu wa zitsanzo | Mtundu Wogwiritsa Ntchito |
| HWTS-3012 | Wogulitsa Wotulutsa | Kugwiritsa ntchito mankhwala a Liquaffoction zitsanzo za Sputum, yapeza nambala yojambulidwa yoyamba, zida zamakina Sutong 20230047. | mbala | |
| Hwts-ngs-p00021 | Chingwe chodziwitsa chiyero cha chifuwa cha chifuwa chachikulu (njira yolumikizira) | Zosasinthika (madzi osungirako) hypersensitivity) hypersensitivity perperia - matumbo opanda chifuwa cha m'mapapo. Zitsanzo za anthu zimawakayikira kutenga kachilomboka kapena kulibe tuberculosis a tebobacciterias adasanthula pa metageniphy anapatsidwa. | Magazi otupira, alveolar amadzimadzi, hydrotorax ndi ascie, amayang'ana mopumira, madzi amadzimadzi. | Mbadwo Wachiwiri |
| HWTS-NGS-T001 | Mycoabacterium Kulemba ndi Kukana Mankhwala Kulembetsa Mankhwala (Njira Yakukweza) | Mayeso a mycoabacterium, kuphatikiza mtbc ndi 187 nts;Kuzindikira mankhwala osokoneza bongo a Mycobacterium matenda 13 ndi mankhwala 16 okhala ndi masinthidwe azaka zosintha mankhwala osokoneza bongo. | Sputum, alveolar amadzimadzi amadzi, hydrotorax ndi ascrota, amayang'ana mopumira, madzi amadzimadzi. | Chachiwiri / Chachitatu M'badwo Wawiri |
Mfundo Zazikulu: Hwts-NGS-T001 Mycobacterium Kulemba ndi Kukana Mankhwala Opezekanso
Kuyambitsa Zoyambitsa
Zogulitsazo zimakhazikitsidwa ndi mankhwala oyamba ndi achiwiri ndi achiwiri omwe afotokozedwawo Omwe hycobacterium chifuwa chachikulu chosinthira, komanso mtundu wina wotsutsa wa mankhwala ndi masinthidwe osintha malinga ndi kufufuza ndi ziwerengero za malipoti othamangitsa kunyumba ndi kunja.
Kuzindikiritsa kuzindikirika kumakhazikitsidwa ndi zingwe za NTM zomwe zidafotokozedwa mwachidule mu NTM malangizo omwe amafalitsidwa ndi Newn Jounculosis ndi matenda opumira komanso mgwirizano wa akatswiri. Pulogalamu yopangidwa yopangidwa imatha kukulitsa, kutsatira ndi kudziwitsa mitundu yopitilira 190 NTM.
Kudzera muukadaulo wambiri wa PCR Zogulitsa zomwe Amplified zitha kupangidwa mu malaibulale a m'badwo wachiwiri kapena am'mibadwo, nsanja zonse za m'badwo uno ndi wam'mibadwo zimatha kuphatikizidwa ndi mawonekedwe okwanira kuti apeze zambiri zotsatizana ndi zomwe akufuna. Poyerekeza ndi masinthidwe odziwika omwe ali patsamba la MyCaback (kuphatikiza omwe a MyCobacterium Perbelog Yovuta ndi Chiyanjano Chake Ndi Kukana Mankhwala), kusintha kwa mankhwala a Anti-chifuwa Wophatikizidwa ndi sputum sputum temple njira ya macro & ma scro-mayeso a acid acid kukula kwa njira zamalonda (nthawi khumi kuposa njira zachikhalidwe) zomwe zingathetsedwe mwachindunji amagwiritsidwa ntchito mwachindunji ku zitsanzo zamankhwala.
Kuzindikira Zamalonda
34Kukaniza Mankhwala Ogwirizana ndi Mankhwala a18anti-chifuwa chachikulu ndi6Mankhwala a NTM adapezeka, chophimba297Masamba Okana Mankhwala; Mitundu khumi ya a Mycoabacterium chifuwa chachikulu komanso kuposa190mitundu ya nts adapezeka.
Gome 1: Zambiri za 18 + 6 Mankhwala + 190 + ntm
Phindu lazinthu
Kusintha Kwachipatala: Zitsanzo za sputum zitha kupezeka mwachindunji ndi mtundu wodzipereka popanda chikhalidwe.
Ntchito yoyesera ndi yosavuta: koyambirira kuzungulira opaleshoni ndi yosavuta, ndipo ntchito yomanga laibulale imamalizidwa mu maola atatu, zomwe zimawongolera ntchito yogwira ntchito.
Kulemba mokwanira ndi kukana kwa mankhwala: kuphimba masamba am'manja ndi kukana mankhwala a MTB ndi NTM, omwe ali ndi malingaliro olondola ndi mapulani odziyerekeza, ndikupanga malipoti a kusanthula amodzi.
Kugwirizana: Kugwirizana kwa zinthu, kumasinthira ku mailtorm ilm ndi mig / pat.
Kutanthauzira kwa Zogulitsa
| Khodi Yogulitsa | Dzina lazogulitsa | Nsanja ya dipuno | kulembana |
| HWTS-NGS-T001 | Mycoabacterium Kulemba ndi Kukana Mankhwala Kulimbana ndi Katundu (Njira Yamphatso ya Akuluxx) | Ont, Audina, Mgi, salus Pro | 16 / 96rxn |
Post Nthawi: Jan-23-2024