Mwathunthu-Automated Sample-to-Yankho C. Diff Infection Kuzindikira

Nchiyani chimayambitsa matenda a C. Diff?

Matenda a C.Diff amayamba ndi bakiteriya yotchedwa bacteriaClostridioides difficile (C. difficile), zomwe nthawi zambiri zimakhala m'matumbo popanda vuto. Komabe, mabakiteriya a m'matumbo akasokonekera, ndipo nthawi zambiri amagwiritsa ntchito maantibayotiki ambiri, C. difficile imatha kukula kwambiri ndikutulutsa poizoni, zomwe zimayambitsa matenda.

Bakiteriyayu alipo onse awiritoxigenicndi mitundu yopanda poizoni, koma mitundu ya toxigenic yokha (poizoni A ndi B) imayambitsa matenda. Amayambitsa kutupa mwa kusokoneza ma cell a epithelial m'matumbo. Poizoni A kwenikweni ndi enterotoxin yomwe imawononga matumbo a m'matumbo, kukulitsa kutulutsa, ndikukopa ma cell achitetezo omwe amamasula ma cytokines otupa. Poizoni B, cytotoxin yamphamvu kwambiri, imayang'ana pa actin cytoskeleton ya ma cell, zomwe zimapangitsa kuti ma cell azizungulira, atsekeke, ndipo pamapeto pake maselo amafa. Pamodzi, poizoniyu amayambitsa kuwonongeka kwa minofu ndi kuyankha mwamphamvu kwa chitetezo chamthupi, zomwe zimawoneka ngati colitis, kutsekula m'mimba, ndipo nthawi zambiri, pseudomembranous colitis - kutupa kwakukulu kwa m'matumbo.

Zikuyenda bwanjiC. Diffkufalitsa?

C.Diff imafalikira mosavuta. Zilipo m'zipatala, zomwe nthawi zambiri zimapezeka ku ICU, m'manja mwa ogwira ntchito m'chipatala, pansi pazipatala ndi m'manja, pazitsulo zamagetsi zamagetsi, ndi zipangizo zina zamankhwala ...

Zowopsa za C. Diff Infection

• ●Kugonekedwa m'chipatala kwa nthawi yayitali;

• ●mankhwala antimicrobial;

• ●Chemotherapy wothandizira;

• ●Opaleshoni yaposachedwa (manja am'mimba, chodutsa m'mimba, opaleshoni yamatumbo);

• ●Naso-chakudya cham'mimba;

• ●Isanafike C. diff matenda;

Zizindikiro za C. Diff matenda

C. matenda a diff akhoza kukhala ovuta kwambiri. Anthu ambiri amakhala ndi vuto lotsegula m'mimba komanso kusapeza bwino m'mimba. Zizindikiro zodziwika bwino ndi izi: kutsekula m'mimba, kupweteka m'mimba, nseru, kusafuna kudya, kutentha thupi.

Pamene matenda a C. diff akuchulukirachulukira, padzakhala chitukuko cha mtundu wovuta kwambiri wa C. diff wotchedwa colitis, pseudomembranous enteritis ngakhale imfa.

Matendawa C. Diff Matenda

Chikhalidwe cha Bakiteriya:Zomverera koma zowononga nthawi (2-5days), sizingathe kusiyanitsa mitundu ya toxigenic ndi yopanda toxigenic;

Chikhalidwe cha Toxin:imazindikiritsa mitundu ya poizoni yomwe imayambitsa matenda koma yowononga nthawi (masiku 3-5) komanso osamva bwino;

Kuzindikira kwa GDH:kudya (1-2hrs) ndi zotsika mtengo, zokhudzidwa kwambiri koma sangathe kusiyanitsa mitundu ya toxigenic ndi yopanda poizoni;

Cell Cytotoxicity Neutralization Assay (CCNA): imazindikira poizoni A ndi B ndi kukhudzika kwakukulu koma nthawi yambiri (2-3days), ndipo imafuna malo apadera ndi ogwira ntchito ophunzitsidwa;

Poizoni A/B ELISA: Mayeso osavuta komanso ofulumira (1-2hrs) okhala ndi chidwi chochepa komanso zolakwika zabodza pafupipafupi;

Mayeso a Nucleic Acid Amplification (NAATs): Rapid (1-3hrs) komanso tcheru kwambiri & yeniyeni, kuzindikira majini udindo kupanga poizoni;

Kuonjezera apo, kuyezetsa kujambula matumbo, monga CT scans ndi X-rays, kungagwiritsidwenso ntchito kuthandizira kuzindikira C. diff ndi zovuta za C. diff, monga colitis.

Chithandizo cha C. Diff matenda

Njira zambiri zothandizira zilipoC. matenda osiyanasiyana. Pansipa pali zosankha zabwino kwambiri:

• ●Maantibayotiki a pakamwa monga vancomycin, metronidazole kapena fidaxomicin amagwiritsidwa ntchito kwambiri chifukwa mankhwalawa amatha kudutsa m'mimba ndikufika m'matumbo momwe mabakiteriya a C. diff amakhala.

• ●Mtsempha wa metronidazole angagwiritsidwe ntchito pochiza ngati matenda a C. diff ali ovuta.

• ●Kuika m'matumbo a tizilombo tating'onoting'ono tawonetsa kuthandizira pochiza matenda a C. diff pafupipafupi komanso matenda oopsa a C. diff omwe sayankha maantibayotiki.

• ●Opaleshoni ingakhale yofunikira pazovuta kwambiri.

Diagnostic solution kuchokera ku MMT

Poyankha kufunikira kozindikira mwachangu, molondola kwa C. difficile, tikuyambitsa zida zathu zatsopano za Nucleic Acid Detection Kit za Clostridium difficile toxin A / B jini, kupatsa mphamvu akatswiri azachipatala kuti azindikire msanga komanso molondola komanso kuthandizira kulimbana ndi matenda omwe amapezeka m'chipatala.

图片链接:

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  ●Kumverera Kwambiri: Imazindikira motsika ngati200 CFU/mL,;

• 
  
  ●Zolondola Zolondola: Imazindikiritsa bwino jini ya C. difficile toxin A/B, kuchepetsa zabwino zabodza;

• 
  
  ●Kuzindikira Pathogen Mwachindunji: Amagwiritsa ntchito kuyesa kwa nucleic acid kuti adziwe mwachindunji majini a poizoni, kukhazikitsa muyezo wagolide wowunikira.

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  ●Zogwirizana kwathunthu ndizida zazikulu za PCR zomwe zimayang'anira ma lab ambiri;

Chitsanzo-ku-YankhoYankho pa Macro & Micro-Test's AIO800 Mobile PCR Lab

 

• ●Zitsanzo-Kuyankha Zodzichitira - Kwezani machubu oyambirira (1.5-12 mL) mwachindunji, kuchotsa mapaipi amanja. Kutulutsa, kukulitsa, ndi kuzindikira ndizodziwikiratu, kumachepetsa nthawi komanso zolakwika zamunthu.

• ●Chitetezo Chowononga Zosanjikiza Zisanu ndi zitatu - Kuthamanga kwa mpweya wolowera, kupanikizika kolakwika, kusefera kwa HEPA, kutsekereza kwa UV, kutsekedwa kosindikizidwa, ndi zina zotetezedwa zophatikizika zimateteza ogwira ntchito ndikuwonetsetsa zotsatira zodalirika pakuyezetsa kwambiri.

Kuti mudziwe zambiri:

https://www.mmtest.com/nucleic-acid-detection-kit-for-clostridium-difficile-toxin-ab-gene-fluorescence-pcr-product/

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