Chitsanzo Chokha Chokha Choyankha C. Kuzindikira Matenda Osiyanasiyana

Kodi n’chiyani chimayambitsa matenda a C. Diff?

Matenda a C.Diff amayamba chifukwa cha bakiteriya wotchedwaClostridioides difficile (C. difficile), zomwe nthawi zambiri zimakhala m'matumbo mopanda kuvulaza. Komabe, pamene mabakiteriya m'matumbo asokonezeka, nthawi zambiri kugwiritsa ntchito maantibayotiki ambiri, C. difficile imatha kukula kwambiri ndikupanga poizoni, zomwe zimapangitsa kuti matenda ayambe.

Bakiteriya iyi ilipo m'maselo onse awiripoizonindi mitundu yosayambitsa poizoni, koma mitundu yokha ya poizoni (toxin A ndi B) ndi yomwe imayambitsa matenda. Amayambitsa kutupa mwa kusokoneza maselo a m'mimba. Toxin A makamaka ndi enterotoxin yomwe imawononga mkati mwa matumbo, kuwonjezera kulowa kwa madzi, ndikukopa maselo oteteza thupi omwe amatulutsa ma cytokines otupa. Toxin B, cytotoxin yamphamvu kwambiri, imayang'ana cytoskeleton ya actin ya maselo, zomwe zimapangitsa kuti maselo azizungulira, azigawikana, ndipo pamapeto pake kufa kwa maselo. Pamodzi, poizoniyu amachititsa kuwonongeka kwa minofu ndi chitetezo champhamvu cha mthupi, chomwe chimawonekera ngati colitis, kutsegula m'mimba, komanso nthawi zina, pseudomembranous colitis - kutupa kwakukulu kwa m'matumbo.

Kodi zimatheka bwanjiKusiyana kwa C.kufalitsa?

C.Diff imafalikira mosavuta. Imapezeka m'zipatala, nthawi zambiri imapezeka m'ma ICU, m'manja mwa ogwira ntchito kuchipatala, pansi pa zipatala ndi m'manja, pa ma thermometer amagetsi, ndi zida zina zachipatala...

Zinthu Zoopsa za Matenda a C. Diff

• ●Kugonekedwa m'chipatala kwa nthawi yayitali;

• ●mankhwala oletsa tizilombo toyambitsa matenda;

• ●Mankhwala a chemotherapy;

• ●Opaleshoni yaposachedwa (manja a m'mimba, njira yodutsa m'mimba, opaleshoni ya m'matumbo akulu);

• ●Zakudya za m'mimba ndi m'mphuno;

• ●Matenda a C. diff asanachitike;

Zizindikiro za matenda a C. Diff

Matenda a C. diff angakhale osasangalatsa kwambiri. Anthu ambiri amakhala ndi kutsegula m'mimba kosalekeza komanso kusasangalala m'mimba. Zizindikiro zodziwika bwino ndi izi: kutsegula m'mimba, kupweteka m'mimba, nseru, kusowa chilakolako cha chakudya, komanso kutentha thupi.

Pamene matenda a C. diff akuchulukirachulukira, padzakhala chitukuko cha mtundu wovuta kwambiri wa C. diff wotchedwa colitis, pseudomembranous enteritis komanso imfa.

Kuzindikira matendaMatenda a C. Diff

Chikhalidwe cha Mabakiteriya:Yovuta koma imatenga nthawi (masiku 2-5), singathe kusiyanitsa mitundu ya poizoni ndi yosakhala poizoni;

Chikhalidwe cha Poizoni:imazindikira mitundu ya poizoni yomwe imayambitsa matenda koma imatenga nthawi (masiku 3-5) komanso yosakhudzidwa kwambiri;

Kuzindikira GDH:mwachangu (maola 1-2) komanso yotsika mtengo, yodziwika bwino koma singathe kusiyanitsa mitundu ya poizoni ndi yosakhala poizoni;

Kuyesa Kusagwiritsa Ntchito Mankhwala Ochepetsa Matenda a Cell Cytotoxicity (CCNA):amazindikira poizoni A ndi B ndi mphamvu yowonjezereka koma imatenga nthawi (masiku awiri mpaka atatu), ndipo amafuna malo apadera ndi antchito ophunzitsidwa bwino;

Poizoni A/B ELISA: Kuyesa kosavuta komanso kwachangu (maola 1-2) ndi mphamvu yochepa komanso nthawi zambiri zolakwika;

Mayeso a Kukulitsa kwa Nucleic Acid (NAATs): Yofulumira (maola 1-3) komanso yodziwika bwino komanso yeniyeni, kuzindikira majini omwe amachititsa kupanga poizoni;

Kuphatikiza apo, mayeso ojambulira kuti aone matumbo, monga CT scans ndi X-ray, angagwiritsidwenso ntchito pothandiza kuzindikira C. diff ndi mavuto a C. diff, monga colitis.

Chithandizo cha matenda a C. Diff

Pali njira zambiri zochiritsira zomwe zilipoC. matenda osiyanasiyanaNazi njira zabwino kwambiri:

• ●Mankhwala opha tizilombo toyambitsa matenda monga vancomycin, metronidazole kapena fidaxomicin amagwiritsidwa ntchito kwambiri chifukwa mankhwalawa amatha kudutsa m'mimba ndikufikira m'matumbo momwe mabakiteriya a C. diff amakhala.

• ●Metronidazole yolowetsedwa m'mitsempha ingagwiritsidwe ntchito pochiza ngati matenda a C. diff ndi oopsa.

• ●Kusamutsa tizilombo toyambitsa matenda m'chimbudzi kwasonyeza kuti ndi kothandiza pochiza matenda opatsirana pafupipafupi a C. diff ndi matenda oopsa a C. diff omwe sayankha mankhwala opha majeremusi.

• ●Opaleshoni ingafunike pa milandu yoopsa.

Njira yothetsera matenda kuchokera ku MMT

Pofuna kuthana ndi kufunika kozindikira mwachangu komanso molondola za C. difficile, tayambitsa Nucleic Acid Detection Kit yathu yatsopano yopezera poizoni wa Clostridium difficile wa jini la A/B, zomwe zimathandiza akatswiri azaumoyo kuti azitha kuzindikira matenda msanga komanso molondola komanso kuthandizira kulimbana ndi matenda omwe amabwera kuchipatala.

图片链接:

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  ●Kuzindikira Kwambiri: Imazindikira mpaka200 CFU/mL,;

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  ●Kulunjika Molondola: Amazindikira bwino lomwe jini la C. difficile toxin A/B, kuchepetsa zabwino zabodza;

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  ●Kuzindikira Mwachindunji Matenda Oyambitsa Matenda: Amagwiritsa ntchito mayeso a nucleic acid kuti adziwe mwachindunji majini a poizoni, ndikukhazikitsa muyezo wabwino kwambiri wodziwira matenda.

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  ●Yogwirizana kwathunthu ndizida zazikulu za PCR zomwe zimayang'ana ma laboratories ambiri;

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