Kuzindikira kwa BCR-Abl kwa CML

Matenda a myelogenousleukemia (cml) ndi matenda owopsa a hematopoietic tsinde. Oposa 95% ya odwala cml amakhala ndi Philadelphia chromosome (pH) m'maselo awo amwazi. Ndipo bcr-abl bun flar imapangidwa ndi tracloction pakati pa Abl Proto-Oncogene (9Q. a chromosome 22 (22Q11). Ma protein ake okhala ndi protekion omwe ali ndi Tyrosine Kinase (TK) ntchito, ndikuyambitsa njira, pikha, ndikupanga maselo owoneka bwino, ndipo potero amayambitsa kupezeka kwa cml.

BCR-ABL RUQU, yomwe ndiyofunikira pakukula kwa cml, imakhala yowonjezera matenda wa cml. Kuzindikira kwake kumathandizira kuwunika kwa wodwala'Kuyankha ku Tyrosine Kinase inhibitors (Tkis) ndikulosera za leukemia, zomwe ndizofunikira pakuwongolera kasamalidwe ka CML.

BCR-ABLZithunzi za jini zolembetsa ku NewKuchokera ku Macro & Mayeso oyeserera kuti azindikire BCR-ABL mu odwala cml, amathandizira kuzindikira kwa ma cml ndi magetsi omwe amalandila chithandizo chamankhwala Kuti mukonze njira zochizira zogwiritsira ntchito moyenera.bcr-Abl Fiision Gene, yemwendichofunikaPakukula kwa cml,Amakhala ngati chiwembu chofufumitsaofCml. Kudziwika kwake kumathandizayang'anirawodwala'sKuyankha ku Tyrosine Kinase inhibitors (Tkis)ndiamaneneratu za leukemia, zomwe ziliofunikato amphamvuCmlKusamalira mwa kulephera.

Mtundu wa BCR-ABL-ABL-ABL Kuchokera ku Macro & Mayeso oyeserera a BCR-ABL mu odwala cml, amathandiziraCmlkufufuzandizipoloweMchiritso MankhwalatoOkhoeNjira zochizira zogwiritsira ntchito moyenera.

OmvetsaDZosakwana:Nthawi yomweyokufufuzawa3Zofananira Zofala Zibadwa (P210, P190, P230)wazokutira zazikulu ndiKupewa ku milandu yosowa;

Chidwi chachikulu:Mtundu wamadzimadzi umazindikira kuti zifanizirondi lodza 1000 makope / ml,ndi mtundu wa lyophilizedof 500 makope / ml;

ChabwinoACCCRY: Iamayikulamulandi ung enzyme kuti mupewe zabwino zabodza&Zovuta;

Kugwira Ntchito kosavuta ndi luso:Ntchito Yotsekedwa,zopanda zinthuPosachedwa,ndikufufuzamkatiMphindi 60waCholinga ndi zotsatira zodalirika;

ZambiriZosankha:Madzimadzi ndi matembenuzidwe a lyophilid azosankha za makasitomala;

Kugwirizana Kwambiri:Yogwirizana ndi njira zambiri za PCR yolumikizidwa kwambiri.