Kuzindikira Kwambiri kwa BCR-ABL kwa Chithandizo cha CML

Chronic myelogenousleukemia (CML) ndi matenda oopsa a clonal a hematopoietic stem cell. Oposa 95% ya odwala CML amakhala ndi Philadelphia chromosome (Ph) m'maselo awo a magazi. Ndipo BCR-ABL fusion jini imapangidwa ndi translocation pakati pa ABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) pa mkono wautali wa chromosome 9 (9q34) ndi breakpoint cluster region (BCR) jini pa mkono wautali wa chromosome 212 (22q12). Mapuloteni ake ophatikizika omwe amapangidwa ndi jini iyi ali ndi ntchito ya tyrosine kinase (TK), ndipo imayendetsa njira zake zolozera pansi (monga RAS, PI3K, ndi JAK/STAT) kulimbikitsa kugawikana kwa ma cell ndikuletsa apoptosis ya cell, kupangitsa kuti maselo azichulukana moyipa, ndikupangitsa kuti CML ichitike.

BCR-ABL fusion jini, yomwe ili yofunika kwambiri pakukula kwa CML, imakhala ngati chizindikiro chachikulu cha matenda. pa CML. Kuzindikira kwake kumathandiza kuwunika odwala'Kuyankha kwa tyrosine kinase inhibitors (TKIs) ndikulosera kubwereza kwa khansa ya m'magazi, yomwe ndi yofunikira kuti pakhale kasamalidwe ka odwala CML.

Munthu BCR-ABLFusion Gene Mutation Detection Kitkuchokera ku Macro & Micro-Test kuti mudziwe bwino za BCR-ABL mwa odwala CML, imathandizira kuzindikira kwa CML ndikuwongolera chithandizo chamankhwala chomwe chalunjika kukhathamiritsa njira zochiritsira zothandizira odwala bwino.BCR-ABL fusion gene, kutindizofunikamu chitukuko cha CML,imagwira ntchito ngati cholembera chofunikiraofCML. Kuzindikira kwake kumathandizakuyang'anirawodwala'skuyankha kwa tyrosine kinase inhibitors (TKIs)ndiamalosera kuyambiranso kwa leukemia, amenezofunikato ogwiraCMLkasamalidwe ka odwala.

Anthu a BCR-ABL Fusion Gene Mutation Detection Kit kuchokera ku Macro & Micro-Test kuti mudziwe bwino za BCR-ABL mwa odwala CML, amathandizaCMLmatendandiotsogoleraThandizo lachipatala lolunjikatooptimizeenjira zochiritsira zothandizira odwala bwino.

ZokwaniraDetection:Nthawi imodzikuzindikiraza3majini ophatikizana (P210, P190, P230)zayotakata Kuphunzira ndikupewa milandu yophonya;

Kutengeka Kwambiri:Mtundu wamadzimadzi umazindikira majini ophatikizikandi LoD1000 makopi / ml,ndi Baibulo la lyophilizedof 500 makopi / ml;

Zabwino kwambiriAkulondola: Izamkatikulamulirandi UNG enzyme kuti mupewe zolakwika&zoipa;

Ntchito Yosavuta ndi Mwachangu:Opaleshoni ya chubu yotsekedwa,wopanda mankhwalapambuyo processing,ndikuzindikiramkatiMphindi 60zazolinga ndi zodalirika zotsatira;

ZambiriZosankha:Mabaibulo amadzimadzi ndi lyophilized pazosankha zamakasitomala;

Kugwirizana Kwambiri:Imagwirizana ndi machitidwe ambiri a PCR kuti azitha kupezeka ndi labu.