Kuzindikira Kofunika Kwambiri kwa BCR-ABL pa Chithandizo cha CML

Matenda a myelogenousleukemia (CML) ndi matenda oopsa a clonal a maselo oyambira a hematopoietic. Odwala oposa 95% a CML amakhala ndi Philadelphia chromosome (Ph) m'maselo awo amagazi. Ndipo jini ya BCR-ABL fusion imapangidwa ndi translocation pakati pa ABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) pa mkono wautali wa chromosome 9 (9q34) ndi jini ya breakpoint cluster region (BCR) pa mkono wautali wa chromosome 22 (22q11). Puloteni yake yosakanikirana yomwe imapangidwa ndi jini iyi ili ndi ntchito ya tyrosine kinase (TK), ndipo imayendetsa njira zake zotsatsira zizindikiro (monga RAS, PI3K, ndi JAK/STAT) kuti ilimbikitse kugawikana kwa maselo ndikuletsa apoptosis ya maselo, zomwe zimapangitsa maselo kuchulukana kwambiri, motero zimayambitsa CML.

Jini losakanikirana la BCR-ABL, lomwe ndi lofunika kwambiri pakukula kwa CML, limagwira ntchito ngati chizindikiro chofunikira chodziwira matenda. Kuzindikira kwa CML kumathandiza kuyang'anira wodwala'Kuyankha kwa tyrosine kinase inhibitors (TKIs) ndi kulosera kubwereranso kwa leukemia, komwe ndikofunikira kwambiri kuti odwala a CML azitha kulandira chithandizo choyenera.

Anthu BCR-ABLKiti Yodziwira Kusintha kwa Majini a Fusionkuchokera ku Macro & Micro-Test kuti azindikire bwino BCR-ABL mwa odwala a CML, zimathandiza kuzindikira matenda a CML ndikuwongolera chithandizo chamankhwala cholunjika kukonza njira zochiritsira kuti odwala azitha kulandira chithandizo chabwino. BCR-ABL fusion gene, zomwendichofunikapakukula kwa CML,imagwira ntchito ngati chizindikiro chofunikira chodziwira matendaofCMLKuzindikira kwake kumathandizachowunikirawodwala'sKuyankha kwa tyrosine kinase inhibitors (TKIs)ndiakuneneratu kubwereranso kwa khansa ya m'magazi, zomwe ndichofunikirato ogwira ntchitoCMLkasamalidwe ka odwala.

Kiti Yodziwira Kusintha kwa Majini a BCR-ABL ya Anthu kuchokera ku Macro & Micro-Test kuti azindikire bwino BCR-ABL mwa odwala a CML, zothandiziraCMLmatendandiatsogolerichithandizo chamankhwala cholunjikatooptimizenjira zochiritsira zoyendetsera bwino odwala.

ZonseDkuyesa:Nthawi imodzikuzindikirachifukwa cha3majini ophatikizana wamba (P210, P190, P230)chifukwa chakufalikira kwakukulu ndikupewa milandu yosowa;

Kuzindikira Kwambiri:Mtundu wamadzimadzi umazindikira majini osakanikiranandi LoDya makope 1000/mL,ndi mtundu wa lyophilizedof Makopi 500/mL;

Zabwino kwambiriAkulondola: Imkatikuwongolerandi enzyme ya UNG kuti apewe zotsatira zabodza& zoipa;

Kugwira Ntchito Mosavuta ndi Mwachangu:Kugwira ntchito kwa chubu chotsekedwa,wopanda zinthukukonza pambuyo pake,ndikuzindikiramkatiMphindi 60chifukwa chazotsatira zenizeni komanso zodalirika;

ZambiriZosankha：Mabaibulo amadzimadzi ndi lyophilized a zosankha za makasitomala;

Kugwirizana Kwambiri:Imagwirizana ndi machitidwe ambiri a PCR kuti igwiritsidwe ntchito kwambiri m'ma laboratories.