Clostridioides difficile ndi imodzi mwa matenda omwe amabwera chifukwa cha matendawa.Zifukwa zazikulu zoyambitsa matenda opatsirana m'mimba okhudzana ndi thanziPadziko lonse lapansi. Vutoli ndi lalikulu kwambiri pakati pa odwala okalamba, anthu omwe ali m'zipatala, okhala m'zipatala zosamalira ana kwa nthawi yayitali, komanso odwala omwe amalandira maantibayotiki ambiri.
Komabe kupeza matenda a C. difficile (CDI) kumabweretsa vuto lapadera.
Mosiyana ndi matenda ambiri a m'mimba, C. difficile nditizilombo toyambitsa matenda tomwe timayambitsa mwayizomwe zingalowe m'matumbo popanda kuyambitsa matenda. Kuyenda kosawonetsa zizindikiro nthawi zambiri kumawonekera m'malo azachipatala, zomwe zikutanthauza kuti kupezeka kwa chamoyo chokha sikutanthauza kuti pali matenda.
Kusiyana kumeneku pakati pa kukhazikika kwa koloni ndi matenda ndi pakati pa matenda amakono a CDI.
Kodi CDI ndi chiyani?
Matenda a matenda amayamba pamene mitundu ya poizoni imapanga poizoni womwe umawononga mucosa ya m'mimba, zomwe zimapangitsa zizindikiro monga:
- · Kutsegula m'mimba kosamveka bwino
- · Kupweteka m'mimba
- · Malungo
- · Leukocytosis
- · Matenda a m'matumbo
Malinga ndi kusintha kwa 2021 kwa malangizo a European Society of Clinical Microbiology and Infectious Diseases (ESCMID), kuyezetsa kwa labotale kuyenera kuchitika makamaka kwa odwala omwe ali ndi matenda otsegula m'mimba omwe akuwonetsa kuti ali ndi CDI.
Malangizowa amafotokoza kuti kutsegula m'mimba ndi ndowe zitatu kapena kuposerapo mkati mwa maola 24 ndipo akugogomezera kuti zomwe zapezeka m'ma laboratories ziyenera kukhala nthawi zonsekutanthauziridwa mogwirizana ndi kuwonetsedwa kwachipatala.
Zotsatira zabwino zokha za labotale siziyenera kuyerekezedwa ndi CDI zokha.
ESCMID: Kuphatikiza Kuyesa Zachipatala ndi Kuyesa kwa Laboratory
Pofuna kupititsa patsogolo kulondola kwa matenda pamene akuchepetsa kuchuluka kwa matenda, ESCMID imalimbikitsa njira yodziwira matenda m'njira zambiri.
Gawo loyamba la kusanthula lingagwiritsidwe ntchito:
- · Glutamate dehydrogenase (GDH), kapena
- · Kuyesa Kukulitsa Asidi wa Nyukiliya (NAAT)
Njira zonsezi zimapereka chidziwitso chapamwamba pozindikira odwala omwe ali ndi C. difficile.
Poyerekeza ndi GDH,NAAT imapereka chidziwitso chabwino kwambiri mwa kuzindikira majini okhudzana ndi poizoni omwe amanyamula mitundu ya poizonim'malo mongodziwa kuti pali chamoyo chilichonse.
Komabe, ESCMID imanenanso kuti kudalira NAAT yokha kungayambitse matenda opitirira muyeso chifukwa majini a poizoni amatha kupezeka mwa anthu omwe ali ndi zizindikiro kapena odwala omwe alibe matenda okhudzana ndi matenda.
Pachifukwa ichi, zotsatira zabwino zowunika zimatanthauziridwa bwino pamodzi ndi zotsatira za kusanthula kwa poizoni ndi zomwe zapezeka kuchipatala.
Njira iyi imathandiza kusiyanitsa:
- · CDI yogwira ntchito
- · Kusazindikira zizindikiro za matendawa
- · Matenda oyamba omwe amafunika kuwunikanso kuchipatala
Kuyesa kwa CDI Kogwirizana ndi Malangizo
Pofuna kuthandizira ma laboratories omwe amagwiritsa ntchito njira zowunikira mamolekyu mkati mwa njira zodziwira ma CDI, Macro & Micro-Test imaperekaKiti Yodziwira Nucleic Acid ya Clostridium difficile Toxin A/B Gene (Fluorescence PCR).
Kuyesaku kumazindikira mwachindunjitcdAnditcdBmajini ochokerazitsanzo za ndowe zosapangidwa, zomwe zimathandiza kuzindikira mwachangu mitundu ya C. difficile yomwe imayambitsa poizoni.
Ubwino Waukulu:
-Kukhala ndi mphamvu yochuluka yokhala ndi LoD yotsika ngati:200 CFU/mL/2,000 makope/mL, zomwe zimathandiza kuzindikira modalirika mitundu yotsika ya poizoni.
-Kulimbana ndi poizoni A (tcdAndi poizoni B (tcdB) majini, mayesowa amazindikira makamaka mitundu yomwe imatha kupanga zinthu zazikulu zokhudzana ndi kachilombo ka CDI.
- Kuphatikiza Kosinthasintha kwa Ntchito: Kugwirizana ndi nsanja zazikulu za PCR zenizeni komanso Kuyesa Kokha Kokha pa Eudemon AIO 800
-Chitsimikizo cha IVDR, chosonyeza kutsatira zofunikira zolimba za European In Vitro Diagnostic Regulation ndikuthandizira ma laboratories m'misika yonse ya ku Europe ndi yapadziko lonse lapansi.
Kuthandiza Zisankho Zabwino Zachipatala
Kuzindikira molondola kwa CDI kumafuna zambiri kuposa kungozindikiraC. zovutaZimafunika kuphatikiza zizindikiro zachipatala, zomwe zapezeka mu labotale, komanso kumvetsetsa kusiyana pakati pa kufalikira kwa matendawa ndi matenda.
Mogwirizana ndi malangizo a ESCMID, NAAT yokhala ndi mphamvu yowonjezereka imagwira ntchito yofunika kwambiri pozindikira poizoniC. zovutamavuto monga gawo la njira yonse yodziwira matenda a CDI.
Kudzera mu njira zake zoyesera mamolekyulu zovomerezeka ndi IVDR, Macro & Micro-Test yadzipereka kuthandiza ma laboratories kupereka zotsatira mwachangu komanso zodalirika zomwe zimathandizira zisankho zachipatala zodziwika bwino, njira zothanirana ndi matenda, komanso zotsatira zabwino za odwala.
Nthawi yotumizira: Juni-25-2026