Kuzindikira mRNA ya HR-HPV ya Mtundu 15 - Kumazindikira Kukhalapo ndi NTCHITO ya HR-HPV

Khansa ya pachibelekero, yomwe ndi chifukwa chachikulu cha imfa pakati pa akazi padziko lonse lapansi, imayamba chifukwa cha matenda a HPV. Kuthekera kwa matenda a HR-HPV kumadalira kuchuluka kwa majini a E6 ndi E7. Mapuloteni a E6 ndi E7 amamangirira ku mapuloteni oletsa chotupa p53 ndi pRb motsatana, ndipo amachititsa kuti maselo a pachibelekero achuluke komanso kusintha.

Komabe, kuyezetsa kwa HPV DNA kumatsimikizira kupezeka kwa kachilombo, sikuzindikira pakati pa matenda obisika ndi omwe amalembedwa mwachangu. Mosiyana ndi zimenezi, kuzindikira zolemba za HPV E6/E7 mRNA kumagwira ntchito ngati chizindikiro chapadera cha kuwonetsa kwa kachilombo koyambitsa matenda, motero, ndi chizindikiro cholondola kwambiri cha neoplasia ya intraepithelial ya cervical (CIN) kapena khansa yowononga.

HPV E6/E7 mRNAKuyezetsa magazi kumapereka ubwino waukulu popewa khansa ya pachibelekero:

• Kuwunika Kolondola kwa Zoopsa: Kuzindikira matenda a HPV omwe ali pachiwopsezo chachikulu, kupereka kuwunika kolondola kwa zoopsa kuposa kuyeza kwa HPV DNA.
• Kuyeza Moyenera: Kumathandiza madokotala kuzindikira odwala omwe akufunika kufufuzidwa kwina, kuchepetsa njira zosafunikira.
• Chida Choyesera: Chingagwiritsidwe ntchito ngati chida choyesera chokha mtsogolo, makamaka kwa anthu omwe ali pachiwopsezo chachikulu.
• Mitundu 15 ya Chida Chodziwira MRNA cha Human Papillomavirus E6/E7 Gene Choopsa Kwambiri (Fluorescence PCR) kuchokera ku #MMT, chomwe chimatsimikizira bwino kuti pali matenda opatsirana a HR-HPV, ndi chida chothandiza poyesa HPV ndi/kapena kuyang'anira odwala.

Zinthu zomwe zili mu malonda:

• Kuphimba konse: Mitundu 15 ya HR-HPV yokhudzana ndi khansa ya pachibelekero yaphimbidwa;
• Kuzindikira bwino kwambiri: makope 500/mL;
• Kulunjika kwapamwamba kwambiriPalibe ntchito yofanana ndi cytomegalovirus, HSV II ndi DNA ya majini a munthu;
• Kusunga ndalama: Zolinga zoyesera zomwe zimagwirizana kwambiri ndi matenda omwe angakhalepo, kuti achepetse mayeso osafunikira omwe ali ndi ndalama zowonjezera;
• Kulondola kwabwino kwambiri: IC pa ntchito yonse;
• Kugwirizana kwakukulu: Ndi machitidwe akuluakulu a PCR;