Mycobacterium Tuberculosis Nucleic Acid ndi Rifampicin Resistance

Mycobacterium tuberculosis, yomwe mwachidule imatchedwa Tubercle bacillus, TB, ndi mabakiteriya omwe amayambitsa chifuwa chachikulu. Pakadali pano, mankhwala oyamba oletsa chifuwa chachikulu omwe amagwiritsidwa ntchito kwambiri ndi isoniazid, rifampicin ndi hexambutol, ndi zina zotero. Mankhwala achiwiri oletsa chifuwa chachikulu ndi fluoroquinolones, amikacin ndi kanamycin, ndi zina zotero. Mankhwala atsopano omwe apangidwa ndi linezolid, bedaquiline ndi delamani, ndi zina zotero. Komabe, chifukwa cha kugwiritsa ntchito molakwika mankhwala oletsa chifuwa chachikulu komanso mawonekedwe a khoma la maselo a mycobacterium tuberculosis, mycobacterium tuberculosis imakhala ndi kukana mankhwala ku mankhwala oletsa chifuwa chachikulu, zomwe zimabweretsa zovuta zazikulu popewa ndi kuchiza chifuwa chachikulu.

Rifampicin yakhala ikugwiritsidwa ntchito kwambiri pochiza odwala chifuwa chachikulu cha m'mapapo kuyambira kumapeto kwa zaka za m'ma 1970, ndipo ili ndi zotsatirapo zazikulu. Yakhala njira yoyamba kufupikitsa chithandizo cha chemotherapy cha odwala chifuwa chachikulu cha m'mapapo. Kukana kwa Rifampicin kumachitika makamaka chifukwa cha kusintha kwa majini a rpoB. Ngakhale kuti mankhwala atsopano oletsa chifuwa chachikulu akutuluka nthawi zonse, ndipo mphamvu yachipatala ya odwala chifuwa chachikulu cha m'mapapo yapitirirabe kukula, pakadalibe kusowa kwa mankhwala oletsa chifuwa chachikulu, ndipo vuto la kugwiritsa ntchito mankhwala mopanda nzeru m'chipatala ndi lalikulu. Mwachionekere, chifuwa chachikulu cha Mycobacterium mwa odwala chifuwa chachikulu cha m'mapapo sichingathe kuphedwa kwathunthu munthawi yake, zomwe pamapeto pake zimapangitsa kuti wodwalayo akhale ndi matenda osiyanasiyana, zimatalikitsa nthawi ya matendawa, ndikuwonjezera chiopsezo cha imfa ya wodwalayo.