Mycobacterium Tuberculosis Nucleic Acid ndi Rifampicin Resistance

Mycobacterium tuberculosis , posachedwa ngati Tubercle bacillus, TB, ndi tizilombo toyambitsa matenda timene timayambitsa chifuwa chachikulu.Pakalipano, mankhwala omwe amagwiritsidwa ntchito kwambiri pamzere woyamba wa chifuwa chachikulu ndi isoniazid, rifampicin ndi hexambutol, ndi zina zotero. Mankhwala amtundu wachiwiri oletsa chifuwa chachikulu ndi fluoroquinolones, amikacin ndi kanamycin, ndi zina zotero. Mankhwala atsopano opangidwa ndi linezolid, bedaquiline ndi delamani, ndi zina zotero. Komabe, chifukwa chogwiritsa ntchito molakwika mankhwala odana ndi chifuwa chachikulu komanso mawonekedwe a cell khoma la mycobacterium TB, mycobacterium TB imakulitsa kukana kwa mankhwala ku anti-TB, zomwe zimabweretsa zovuta zazikulu pakupewa ndi kuchiza chifuwa chachikulu.

Rifampicin yakhala ikugwiritsidwa ntchito kwambiri pochiza odwala chifuwa chachikulu cha m'mapapo kuyambira kumapeto kwa zaka za m'ma 1970, ndipo imakhala ndi zotsatirapo zazikulu.Chakhala chisankho choyamba kufupikitsa chemotherapy ya odwala chifuwa chachikulu cha m'mapapo.Kukana kwa Rifampicin kumachitika makamaka chifukwa cha kusintha kwa jini ya rpoB.Ngakhale kuti mankhwala atsopano odana ndi chifuwa chachikulu akutuluka nthawi zonse, ndipo mphamvu yachipatala ya odwala chifuwa chachikulu cha m'mapapo ikupitirizabe kusintha, padakalibe mankhwala oletsa chifuwa chachikulu cha TB, ndipo chodabwitsa cha kugwiritsa ntchito mankhwala osokoneza bongo m'chipatala ndi chochepa kwambiri.Mwachionekere, Mycobacterium TB odwala ndi m`mapapo mwanga chifuwa chachikulu sangathe kuphedwa kwathunthu mu nthawi yake, amene potsirizira pake kumabweretsa madigiri osiyana mankhwala kukana mu thupi la wodwalayo, kutalikitsa njira ya matenda, ndi kumaonjezera ngozi ya imfa ya wodwalayo.