Kukana kwa Chifuwa cha Mycobacterium

Rifampicin yakhala ikugwiritsidwa ntchito kwambiri pochiza odwala chifuwa chachikulu cha m'mapapo kuyambira kumapeto kwa zaka za m'ma 1970, ndipo ili ndi zotsatirapo zazikulu. Yakhala njira yoyamba kufupikitsa chithandizo cha chemotherapy cha odwala chifuwa chachikulu cha m'mapapo. Kukana kwa Rifampicin kumachitika makamaka chifukwa cha kusintha kwa jini la rpoB. Ngakhale kuti mankhwala atsopano oletsa chifuwa chachikulu akutuluka nthawi zonse, ndipo mphamvu yachipatala ya odwala chifuwa chachikulu cha m'mapapo yapitirirabe kukula, pakadalibe kusowa kwa mankhwala oletsa chifuwa chachikulu, ndipo vuto la kugwiritsa ntchito mankhwala mopanda nzeru m'chipatala ndi lalikulu. Mwachionekere, chifuwa chachikulu cha Mycobacterium mwa odwala chifuwa chachikulu cha m'mapapo sichingathe kuthetsedwa kwathunthu munthawi yake, zomwe pamapeto pake zimapangitsa kuti wodwalayo akhale ndi matenda osiyanasiyana, zimatalikitsa nthawi ya matendawa, ndikuwonjezera chiopsezo cha imfa ya wodwalayo. Chida ichi ndi choyenera kuzindikira matenda a Mycobacterium tuberculosis komanso kuzindikira jini loletsa rifampicin, zomwe zimathandiza kumvetsetsa kukana kwa mankhwala a mycobacterium tuberculosis omwe ali ndi odwala, komanso kupereka njira zothandizira malangizo azachipatala.