● Matenda a Chifuwa cha Mycobacteria
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Mycobacterium Tuberculosis Nucleic Acid ndi Rifampicin (RIF)，Resistance (INH)
Kiti iyi imagwiritsidwa ntchito pozindikira DNA ya Mycobacterium tuberculosis mu sputum ya anthu, solid culture (LJ Medium) ndi liquid culture (MGIT Medium), bronchial lavage fluid, ndi kusintha kwa majini mu 507-533 amino acid codon region (81bp, rifampicin resistance determining region) ya rpoB gene ya Mycobacterium tuberculosis rifampicin resistance, komanso kusintha kwa majini m'malo akuluakulu a Mycobacterium tuberculosis isoniazid resistance. Imathandiza kuzindikira matenda a Mycobacterium tuberculosis, ndipo imazindikira majini akuluakulu a rifampicin ndi isoniazid resistance, zomwe zimathandiza kumvetsetsa kukana mankhwala kwa Mycobacterium tuberculosis yomwe yagwidwa ndi wodwalayo.
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Kusintha kwa Mycobacterium Tuberculosis INH
Kiti iyi ndi yoyenera kuzindikira malo akuluakulu osinthika m'masampulu a makoswe a anthu omwe atengedwa kuchokera kwa odwala omwe ali ndi Tubercle bacillus omwe amayambitsa mycobacterium tuberculosis INH: InhA promoter region -15C>T, -8T>A, -8T>C; AhpC promoter region -12C>T, -6G>A; homozygous mutation of KatG 315 codon 315G>A, 315G>C.
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Kukana kwa Chifuwa cha Mycobacterium
Kiti iyi ndi yoyenera kuzindikira kusintha kwa homozygous mutation mu gawo la codon la 507-533 amino acid la jini la rpoB lomwe limayambitsa Mycobacterium tuberculosis rifampicin.
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Mycobacterium Tuberculosis Nucleic Acid ndi Rifampicin Resistance
Kiti iyi ndi yoyenera kuzindikira DNA ya Mycobacterium tuberculosis m'masampulu a sputum a anthu mu vitro, komanso kusintha kwa homozygous mu gawo la codon la 507-533 amino acid la jini la rpoB lomwe limayambitsa kukana kwa Mycobacterium tuberculosis rifampicin.
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DNA ya Mycobacterium Tuberculosis
Ndi yoyenera kuzindikira DNA ya Mycobacterium tuberculosis m'masampulu a anthu, ndipo ndi yoyenera kuzindikira matenda a Mycobacterium tuberculosis.
