Human Cytomegalovirus (HCMV) Nucleic Acid

Human cytomegalovirus (HCMV) ndi membala yemwe ali ndi genome yayikulu kwambiri m'banja la herpes virus ndipo amatha kuyika mapuloteni opitilira 200.HCMV imangokhala pagulu la anthu, ndipo palibe mtundu wa nyama wa matenda ake.HCMV imakhala ndi kubwereza kwapang'onopang'ono komanso kwautali kuti ipange gulu lophatikizika ndi zida zanyukiliya, ndikuyambitsa kupanga matupi ophatikizika a perinuclear ndi cytoplasmic ndi kutupa kwa cell (ma cell akulu), chifukwa chake amatchedwa.Malinga ndi kusiyanasiyana kwa ma genome ndi phenotype, HCMV imatha kugawidwa m'mitundu yosiyanasiyana, yomwe pali mitundu ina ya antigenic, yomwe, komabe, ilibe tanthauzo lachipatala.

HCMV matenda ndi zokhudza zonse matenda, amene kuchipatala kumakhudza angapo ziwalo, ali ndi zizindikiro zovuta ndi zosiyanasiyana, makamaka chete, ndipo angachititse odwala angapo kukhala angapo ziwalo zotupa kuphatikizapo retinitis, chiwindi, chibayo, encephalitis, colitis, monocytosis, ndi thrombocytopenic. purpura.Matenda a HCMV ndi ofala kwambiri ndipo akuwoneka kuti akufalikira padziko lonse lapansi.Ndilofala kwambiri mwa anthu, ndi chiwerengero cha 45-50% ndi oposa 90% m'mayiko otukuka ndi omwe akutukuka kumene, motero.HCMV imatha kugona m'thupi kwa nthawi yayitali.Pamene chitetezo cha mthupi chafooka, kachilomboka kadzatsegulidwa kuti ayambitse matenda, makamaka matenda obwera chifukwa cha khansa ya m'magazi ndi odwala omwe amawaika, ndipo angayambitse necrosis ya chiwalo ndikuyika moyo wa odwala pangozi.Kuphatikiza pa kubereka, kupititsa padera komanso kubereka msanga kudzera mu matenda a intrauterine, cytomegalovirus ingayambitsenso matenda obadwa nawo, kotero kuti matenda a HCMV amatha kukhudza chisamaliro cha usana ndi postnatal komanso khalidwe la anthu.