Nucleic Acid ya Human Cytomegalovirus (HCMV)

Kachilombo ka HIV ka munthu (HCMV) ndi membala wa genome yayikulu kwambiri m'banja la kachilombo ka herpes ndipo kangathe kuyika mapuloteni opitilira 200. HCMV ndi yocheperako pang'ono pakati pa anthu, ndipo palibe chitsanzo cha matenda ake chomwe chimapezeka m'zinyama. HCMV ili ndi kayendedwe kobwerezabwereza pang'onopang'ono komanso kwanthawi yayitali kuti ipange thupi lophatikizana mkati mwa nyukiliya, ndikuyambitsa kupanga matupi ophatikizana a perinuclear ndi cytoplasmic ndi kutupa kwa maselo (maselo akuluakulu), ndichifukwa chake dzinalo. Malinga ndi kusiyana kwa genome yake ndi phenotype, HCMV ikhoza kugawidwa m'mitundu yosiyanasiyana, yomwe pali kusiyana kwina kwa antigenic, komwe, komabe, sikuli kofunikira kuchipatala.

Matenda a HCMV ndi matenda opatsirana m'thupi, omwe amakhudza ziwalo zambiri, amakhala ndi zizindikiro zovuta komanso zosiyanasiyana, nthawi zambiri amakhala chete, ndipo angayambitse odwala ochepa kukhala ndi zilonda m'ziwalo zosiyanasiyana kuphatikizapo retinitis, chiwindi, chibayo, encephalitis, colitis, monocytosis, ndi thrombocytopenic purpura. Matenda a HCMV ndi ofala kwambiri ndipo akuwoneka kuti akufalikira padziko lonse lapansi. Ali ofala kwambiri mwa anthu, ndipo kuchuluka kwa matendawa ndi 45-50% ndi oposa 90% m'maiko otukuka ndi otukuka, motsatana. HCMV imatha kukhala m'thupi kwa nthawi yayitali. Chitetezo cha mthupi chikafooka, kachilomboka kamayambitsidwa kuti kayambitse matenda, makamaka matenda obwerezabwereza mwa odwala a khansa ya m'magazi ndi odwala oikidwa m'thupi, ndipo kangayambitse necrosis ya ziwalo zoikidwa m'thupi ndikuyika moyo wa odwala pachiwopsezo chachikulu. Kuphatikiza pa kubadwa kwa akufa, kutaya mimba ndi kubereka msanga kudzera mu matenda a intrauterine, cytomegalovirus ingayambitsenso zolakwika zobadwa nazo, kotero matenda a HCMV amatha kukhudza chisamaliro cha amayi asanabadwe komanso atabereka komanso ubwino wa anthu.