ALDH Genetic Polymorphism

Jini la ALDH2 (acetaldehyde dehydrogenase 2), limapezeka pa chromosome yaumunthu 12. ALDH2 ili ndi esterase, dehydrogenase ndi reductase ntchito pa nthawi yomweyo. Kafukufuku wasonyeza kuti ALDH2 ndi kagayidwe kachakudya ka nitroglycerin, kamene kamasintha nitroglycerin kukhala nitric oxide, motero imapumula mitsempha yamagazi ndikuwongolera kusokonezeka kwa magazi. Komabe, pali ma polymorphisms mumtundu wa ALDH2, womwe umakhazikika ku East Asia. Mtundu wakuthengo wa ALDH2 * 1/* 1 GG uli ndi mphamvu yamphamvu ya metabolic, pomwe mtundu wa heterozygous uli ndi 6% yokha ya enzyme yakuthengo, ndipo mtundu wa homozygous mutant umakhala ndi zochita za enzyme, zofooka kwambiri ndipo sizingakwaniritse zomwe mukufuna, motero zimavulaza thupi la munthu.