Mycobacterium Tuberculosis INH Resistance

Kufotokozera Kwachidule:

Chidachi chimagwiritsidwa ntchito pozindikira kusintha kwa jini kwa 315th amino acid ya jini ya katG (K315G> C) komanso kusintha kwa jini kwa gawo lolimbikitsa la jini ya InhA (- 15 C>T).

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Dzina lazogulitsa

HWTS-RT002A-Mycobacterium Tuberculosis Isoniazid Resistance Detection Kit (Fluorescence PCR)

Satifiketi

Myanmar FDA

Epidemiology

Isoniazid, mankhwala ofunika kwambiri odana ndi TB omwe adayambitsidwa mu 1952, ndi amodzi mwa mankhwala othandiza kwambiri ophatikiza chithandizo cha TB komanso mankhwala amodzi a chifuwa chachikulu chobisika.

KatG ndiye jini yayikulu yotsekera catalase-peroxidase ndipo kusintha kwa jini kwa katG kumatha kulimbikitsa kaphatikizidwe ka khoma la cell ya mycolic acid, kupangitsa mabakiteriya kugonjetsedwa ndi isoniazid.Mawu a KatG amagwirizana molakwika ndi kusintha kwa INH-MIC, ndipo kuchepa kwa 2 kwa katG kumapangitsa kuti pakhale kuwonjezeka pang'ono kwa 2 kwa MIC.Chifukwa china cha isoniazid kukana mu chifuwa chachikulu cha mycobacterium chimachitika pamene kuika m'munsi, kuchotsa kapena kusintha kumachitika mu InhA gene locus ya mycobacterium tuberculosis.

Channel

Mtengo ROX	inhA (-15C>T) malo ·
CY5	tsamba la katG (315G>C).
VIC (HEX)	IS6110

Magawo aukadaulo

Kusungirako	≤-18 ℃ Mumdima
Alumali moyo	12 miyezi
Mtundu wa Chitsanzo	Makoko
CV	≤5.0%
LoD	1 × 10 pa³mabakiteriya/mL
Mwatsatanetsatane	No-cross reactivity ndi masinthidwe a malo anayi osakanizidwa ndi mankhwala (511, 516, 526 ndi 531) a jini ya rpoB kunja kwa kuchuluka kwa zida zodziwira. Zida Zomwe Zingagwiritsidwe Ntchito: Applied Biosystems 7500 Real-Time PCR Systems Applied Biosystems 7500 Fast Real-Time PCR Systems QuantStudio®5 Real-Time PCR Systems SLAN-96P Real-Time PCR Systems LightCycler®480 Real-Time PCR system LineGene 9600 Plus Real-Time PCR Detection System MA-6000 Real-Time Quantitative Thermal Cycler BioRad CFX96 Real-Time PCR System BioRad CFX Opus 96 Real-Time PCR System