Kusintha kwa KRAS 8

Kusintha kwa mfundo mu jini ya KRAS kwapezeka m'mitundu ingapo ya zotupa za anthu, pafupifupi 17% ~ 25% mutation rate mu chotupa, 15% ~ 30% mutation rate mwa odwala khansa ya m'mapapo, 20% ~ 50% mutation rate mu colorectal cancer. odwala.Chifukwa puloteni ya P21 yomwe ili ndi jini ya K-ras ili pansi pa njira yowonetsera EGFR, pambuyo pa kusintha kwa jini ya K-ras, njira yowonetsera pansi nthawi zonse imakhala yotsegulidwa ndipo sichimakhudzidwa ndi mankhwala omwe amawongoleredwa kumtunda kwa EGFR, zomwe zimabweretsa kupitirizabe. kuchuluka koyipa kwa ma cell.Kusintha kwa jini ya K-ras nthawi zambiri kumapereka kukana kwa EGFR tyrosine kinase inhibitors mwa odwala khansa ya m'mapapo komanso kukana mankhwala odana ndi EGFR antibody mwa odwala khansa yapakhungu.Mu 2008, National Comprehensive Cancer Network (NCCN) idapereka malangizo azachipatala a khansa yapakatikati, yomwe idawonetsa kuti malo osinthika omwe amachititsa kuti ma K-ras ayambitsidwe amakhala makamaka mu ma codon 12 ndi 13 a exon 2, ndipo adalimbikitsa kuti odwala onse omwe ali ndi khansa yapamwamba ya metastatic colorectal akhoza kuyesedwa kusintha kwa K-ras musanalandire chithandizo.Chifukwa chake, kuzindikira mwachangu komanso molondola kusintha kwamtundu wa K-ras ndikofunikira kwambiri pakuwongolera zamankhwala.Chidachi chimagwiritsa ntchito DNA ngati chitsanzo chodziwikiratu kuti iwonetsere momwe zinthu ziliri, zomwe zingathandize asing'anga kuyesa khansa ya colorectal, khansa ya m'mapapo ndi odwala ena otupa omwe amapindula ndi mankhwala omwe amawatsata.Zotsatira zoyezetsa za zidazo ndizongofotokozera zachipatala zokha ndipo siziyenera kugwiritsidwa ntchito ngati njira yokhayo yothandizira odwala payekhapayekha.Madokotala akuyenera kuweruza mwatsatanetsatane zotsatira za kuyezetsa kutengera zinthu monga momwe wodwalayo alili, zizindikiro za mankhwala, momwe angayankhire chithandizo ndi zizindikiro zina za labotale.