Kras 8 masinthidwe

Kufikira masinthidwe mu genes Generas apezeka m'mitundu ingapo yaumunthu, pafupifupi 17% ~ 25% mabilidwe a concle odwala, 20% ~ 50% madontho a concackital khansa odwala. Chifukwa mapuloteni a P21 omwe adasungidwa ndi mtundu wa K-Rass amakhala pansi pa njira yolowera kwa EGFR, Mitundu ya K-RASS itatha, imasakhudzidwa ndi mankhwala oyambira pa egfr, chifukwa chopitilira kuchuluka kwa kuchuluka kwa maselo. Masinthidwe mu k-quad gene nthawi zambiri amasokoneza matenda a Tygrosine Kinase zoletsa zamipikisano ndi odwala anti-egfr antibol odwala khansa. Mu 2008, gulu lokwanira la khansa kwambiri (NCCN) idapereka chipatala cha khansa ya colorectical, chomwe chidafotokoza kuti masinthidwe a K-RAS omwe ayambitsidwa Odwala onse omwe ali ndi khansa yapamwamba kwambiri amatha kuyesedwa kwa K-Ras Vessi asanalandire chithandizo. Chifukwa chake, kufufuza mofulumira komanso molondola matchulidwe sikukufunikira kwakukulu mu chizolowezi chamankhwala. Izi zikugwiritsa ntchito DNA monga zitsanzo zopezera zidziwitso zowunikira zoyenera, zomwe zingathandize madokotala pakuwonetsa khansa ya colorecal, kansalu ndi odwala ena otupa omwe amapindula ndi mankhwala omwe apindula ndi mankhwala. Zotsatira zoyeserera za kukomoka ndizachipatala zokha ndipo siziyenera kugwiritsidwa ntchito ngati njira yokhayo yothandizira odwala. Mankhwalawa ayenera kupanga zigamulo zokwanira pazotsatira zotsatizana monga momwe wodwalayo amakhala nawo, kuwonetsa mankhwala, chithandizo chamankhwala a labotale.