Kusintha kwa majini a ROS1 Fusion kwa Anthu

ROS1 ndi tyrosine kinase ya transmembrane ya banja la insulin receptor. JENI la ROS1 fusion latsimikiziridwa kuti ndi jini lina lofunika kwambiri loyendetsa khansa ya m'mapapo yopanda maselo ang'onoang'ono. Monga choyimira mtundu watsopano wapadera wa mamolekyu, kuchuluka kwa jini la ROS1 fusion mu NSCLC Pafupifupi 1% mpaka 2% ROS1 imasinthidwa kwambiri mu ma exons ake 32, 34, 35 ndi 36. Ikaphatikizidwa ndi majini monga CD74, EZR, SLC34A2, ndi SDC4, ipitiliza kuyambitsa dera la ROS1 tyrosine kinase. JENI la ROS1 lomwe silinagwiritsidwe ntchito bwino limatha kuyambitsa njira zolumikizirana monga RAS/MAPK/ERK, PI3K/Akt/mTOR, ndi JAK3/STAT3, motero limatenga nawo mbali pakufalikira, kusiyanitsa ndi kufalikira kwa maselo otupa, ndikuyambitsa khansa. Pakati pa kusintha kwa ROS1 fusion, CD74-ROS1 imakhala pafupifupi 42%, EZR imakhala pafupifupi 15%, SLC34A2 imakhala pafupifupi 12%, ndipo SDC4 imakhala pafupifupi 7%. Kafukufuku wasonyeza kuti malo omangira ATP a domain catalytic ya ROS1 kinase ndi malo omangira ATP a ALK kinase ali ndi homology yofika 77%, kotero ALK tyrosine kinase small molecule inhibitor crizotinib ndi zina zotero zimakhala ndi mphamvu yochiritsa pochiza NSCLC ndi fusion mutation ya ROS1. Chifukwa chake, kuzindikira ROS1 fusion mutations ndiye maziko ndi maziko otsogolera kugwiritsa ntchito mankhwala a crizotinib.