Munthu ROS1 Fusion Gene Mutation
Dzina la malonda
HWTS-TM009-Human ROS1 Fusion Gene Mutation Detection Kit (Fluorescence PCR)
Satifiketi
CE
Epidemiology
ROS1 ndi transmembrane tyrosine kinase ya banja la insulin receptor. ROS1 fusion jini yatsimikiziridwa ngati jini ina yofunika yoyendetsa khansa ya m'mapapo yopanda maselo yaying'ono. Monga nthumwi ya mtundu watsopano wapadera wa mamolekyulu, zochitika za ROS1 fusion jini mu NSCLC Pafupifupi 1% mpaka 2% ROS1 makamaka imayang'ana kukonzanso jini mu ma exons ake 32, 34, 35 ndi 36. Ikaphatikizidwa ndi majini monga CD74, EZR, SLC34Ivaty ndi SLC34A2 kinase dera. ROS1 kinase yolumikizidwa mosadziwika bwino imatha kuyambitsa njira zolozera kunsi kwa mtsinje monga RAS/MAPK/ERK, PI3K/Akt/mTOR, ndi JAK3/STAT3, potero kutenga nawo gawo pakuchulukira, kusiyanitsa ndi metastasis ya maselo otupa, ndikuyambitsa khansa. Pakati pa masinthidwe osakanikirana a ROS1, CD74-ROS1 imakhala pafupifupi 42%, EZR imakhala pafupifupi 15%, SLC34A2 imakhala pafupifupi 12%, ndipo SDC4 imakhala pafupifupi 7%. Kafukufuku wasonyeza kuti ATP-binding site of catalytic domain of ROS1 kinase ndi ATP-binding site of ALK kinase ali ndi homology mpaka 77%, kotero ALK tyrosine kinase yaing'ono molekyulu inhibitor crizotinib ndi zina zotero zimakhala ndi zotsatira zodziwikiratu zochiritsira pochiza NSCLC ndi fusion mutation ya ROS1. Choncho, kuzindikira kwa kusintha kwa ROS1 fusion ndiye maziko ndi maziko otsogolera kugwiritsa ntchito mankhwala a crizotinib.
Channel
FAM | Rection Buffer 1, 2, 3 ndi 4 |
VIC (HEX) | Reaction Buffer 4 |
Magawo aukadaulo
Kusungirako | ≤-18 ℃ |
Alumali moyo | 9 miyezi |
Mtundu wa Chitsanzo | parafini-ophatikizidwa minofu pathological kapena sliced zitsanzo |
CV | <5.0% |
Ct | ≤38 |
LoD | Chida ichi chimatha kuzindikira masinthidwe ophatikizika otsika mpaka makope 20. |
Zida Zomwe Zingagwiritsidwe Ntchito: | Applied Biosystems 7500 Real-Time PCR SystemsApplied Biosystems 7500 Fast Real-Time PCR Systems SLAN ®-96P Real-Time PCR Systems QuantStudio™ 5 Real-Time PCR Systems LightCycler®480 Real-Time PCR system LineGene 9600 Plus Real-Time PCR Detection System MA-6000 Real-Time Quantitative Thermal Cycler BioRad CFX96 Real-Time PCR System BioRad CFX Opus 96 Real-Time PCR System |
Kuyenda Ntchito
Zopangira zopangira zovomerezeka: RNeasy FFPE Kit (73504) kuchokera ku QIAGEN, Gawo la Paraffin Embedded Tissue Total RNA Extraction Kit(DP439) kuchokera ku Tiangen Biotech(Beijing) Co.,Ltd.