Nyuni ya anthu ya EML4-ALK

Izi zimagwiritsidwa ntchito pofuna kudziwa mitundu 12 ya Eml4-Ask mu jini pa zitsanzo za odwala akhungu a cell mu vicro. Zotsatira zoyeserera ndizachipatala zokha ndipo siziyenera kugwiritsidwa ntchito ngati njira yokhayo yothandizira odwala. Mankhwalawa ayenera kupanga zigamulo zokwanira pazinthu zotsatizana malinga ndi momwe wodwalayo amakhala nawo, kuwonetsa mankhwala, mankhwala ena a labotale. Khansa yam'mapapo ndiye chotupa chotupa kwambiri padziko lonse lapansi, ndipo 80% ~ 85% ya milanduyi ndi khansa yam'mapiri. Chifaniziro chophatikizika cha echinoderm microtuble - monga 4 (Eml4) ndi Aaplastic lymphoma kinase (Alk) ndi mtundu wa P21 ndi P23 miliyoni miliyoni. Pafupifupi mitundu 20 ya matenda apezeka, omwe alipo 10 33% ndi 29% ya odwala omwe ali ndi Eml4-Alk Fision Gene nsclc, motsatana. Ma inribitor oyimiriridwa ndi Crizotinib ang'ono-molekyulu omwe amayang'aniridwa ndi mankhwala omwe amapangidwa kuti azikhala ndi ziwalo za nyerere. Poletsa ntchito ya Alk Tyrosine Kinase dera, ndikuletsa njira zake zosasinthika, potero ndikulepheretsa kukula kwa maselo otupa, kuti akwaniritse mankhwala othandizira. Kafukufuku wazachipatala asonyeza kuti Cricotinib ili ndi oposa 61% mwa odwala omwe ali ndi Eml4-Alk mokakamira, pomwe sizimatha chifukwa cha odwala amtundu wamtundu. Chifukwa chake, kuzindikira kwa EmL4-All Kinasion ndi malo ndi maziko otsogolera kugwiritsa ntchito mankhwala osokoneza bongo.