Anthu EGFR Gene 29 Mutations

Khansara ya m'mapapo yakhala ikuyambitsa kufa kwa khansa padziko lonse lapansi, zomwe zikuwopseza kwambiri thanzi la anthu.Khansara ya m'mapapo yosakhala yaying'ono imakhala pafupifupi 80% ya odwala khansa ya m'mapapo.EGFR pakali pano ndiye chandamale yofunika kwambiri yochizira khansa ya m'mapapo yopanda maselo.Phosphorylation ya EGFR imatha kulimbikitsa kukula kwa maselo a chotupa, kusiyanitsa, kuwukira, metastasis, anti-apoptosis, ndikulimbikitsa chotupa angiogenesis.EGFR tyrosine kinase inhibitors (TKI) ikhoza kuletsa njira yowonetsera EGFR poletsa EGFR autophosphorylation, potero kulepheretsa kuchulukana ndi kusiyanitsa kwa maselo otupa, kulimbikitsa chotupa cell apoptosis, kuchepetsa chotupa angiogenesis, etc.Kafukufuku wambiri wasonyeza kuti chithandizo chamankhwala cha EGFR-TKI chikugwirizana kwambiri ndi momwe EGFR gene mutation imasinthira, ndipo imatha kulepheretsa makamaka kukula kwa maselo otupa omwe ali ndi EGFR gene mutation.Jini ya EGFR ili pa dzanja lalifupi la chromosome 7 (7p12), yokhala ndi kutalika kwa 200Kb ndipo imakhala ndi ma exons 28.Dera losinthidwa limapezeka makamaka mu ma exons 18 mpaka 21, ma codon 746 mpaka 753 kufufutidwa pa akaunti ya exon 19 pafupifupi 45% ndipo kusintha kwa L858R pa exon 21 kumakhala pafupifupi 40% mpaka 45%.Malangizo a NCCN pa Kuzindikira ndi Kuchiza Khansa Yopanda Mapapo Aang'ono Amanena momveka bwino kuti kuyezetsa kusintha kwa majini a EGFR kumafunika pamaso pa EGFR-TKI.Chida choyeserachi chimagwiritsidwa ntchito kutsogolera kasamalidwe ka epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) mankhwala, ndikupereka maziko amankhwala amunthu payekha kwa odwala omwe ali ndi khansa ya m'mapapo yosakhala yaying'ono.Chidachi chimangogwiritsidwa ntchito pozindikira masinthidwe omwe amapezeka mumtundu wa EGFR mwa odwala omwe ali ndi khansa ya m'mapapo yomwe si yaing'ono.Zotsatira zoyezetsa ndizongofotokozera zachipatala zokha ndipo siziyenera kugwiritsidwa ntchito ngati njira yokhayo yothandizira odwala payekhapayekha.Madokotala akuyenera kuganizira momwe wodwalayo alili, zomwe akuwonetsa, komanso chithandizo chamankhwala Zomwe zimachitika ndi zizindikiro zina za labotale ndi zinthu zina zimagwiritsidwa ntchito kuweruza momveka bwino zotsatira zake.