Mtundu waku EGRR 29 masinthidwe

Khansa yam'mapapo tsopano yachititsa kupangitsa kuti khansa ifa padziko lonse lapansi iwopseze thanzi la anthu. Maukadaulo ang'onoang'ono a cell a khansa pafupifupi 80% ya odwala khansa. EGFR ili chithunzi chofunikira kwambiri chazomwe chimachizira khansa yam'madzi yaying'ono. Phosphurytion wa Egfr amatha kulimbikitsa kukula kwa khungu, kusiyanitsa, kuwukira, metastasis, antooptosis, ndikulimbikitsa chotupa. EGFR tyrosine kinase inhibitors (tki) imatha kuletsa njira ya egfr poletsa egfr autophossosis, ndikuchepetsa chotupa cha chotupa, etc., kuti akwaniritse chotupa chotupa. Maphunziro ambiri awonetsa kuti njira yothandizirana ndi Egfr-Tki imagwirizana kwambiri ndi mtundu wa fuko la Egfr, ndipo amatha kuletsa kukula kwa maselo otupa omwe ali ndi fuko la egfr. Mphete ya EGFR ili pamkono wamfupi wa chromosome 7 (7p12), kutalika kwathunthu kwa 200k 9k. Dera lotsitsimutsidwa limapezeka makamaka ku Exons 18 mpaka 21, codion 746 mpaka 752 mpaka 753 deleation za 45% ndi l858r pa exon 21 mpaka 45%. Malangizo a Nyimbo a Nyimbo Zodziwitsa ndi Kuchiza Khansa ya Mapale Ang'onoang'ono Kunena Kuti Makina a EGFR amafunikira EGFR-Tki Administry. Zoyeserera izi zimagwiritsidwa ntchito potsogolera makonzedwe a ectormmal kukula kwa tyrosine kinase innibitor (Egfr-tki) mankhwala osokoneza bongo omwe siang'ono. Izi zimangogwiritsidwa ntchito pofufuza masinthidwe wamba mu gene ya EGFR mwa odwala omwe ali ndi khansa yam'mapiri yaying'ono. Zotsatira zoyeserera ndizachipatala zokha ndipo siziyenera kugwiritsidwa ntchito ngati njira yokhayo yothandizira odwala. Mankhwala ayenera kuganizira momwe wodwalayo alili, zisonyezo, komanso chithandizo chamankhwala ndi zizindikiro zina za labotale ndi zinthu zina zimagwiritsidwa ntchito podikiratu zotsatira zoyeserera.