Clostridium Hafule Glutamate Dehturognase (GDH) ndi Toxin A / B

Clostridium Hardile (CD) ndi woyenera galamati-yabwino Bacillus, yomwe ndi maluwa abwino mthupi la munthu. Flora ina yolepheretsa kuchulukitsa chifukwa cha maantibayotiki omwe amagwiritsidwa ntchito m'mlingo waukulu, ndipo cd amabereka m'thupi la munthu ambiri. CD imagawidwa ndi mitundu yopanga ndi yopanga ndi yopanda poizoni. Mitundu yonse ya CD imatulutsa glutamiate dehydrogenase (GDH) akabereka, ndipo zovuta zonunkhira zokhazokha ndizomwe zimangokhala. Zojambula zopanga poizoni zimatha kutulutsa poizoni ziwiri, a ndi B. Poixin A ndi enterotoxin, yomwe imapangitsa kuti mapilo am'matumbo, matope am'matumbo, hemorrhage ndi necrosis. Poizoni B ndi cytotoxin, yomwe imawononga cytoskeleton, yomwe imayambitsa cynos pyknosis ndi necrosis, ndikuwononga mwachindunji maselo amitundu, chifukwa pseudomembranous colitis.