Clostridium Difficile Glutamate Dehydrogenase (GDH) ndi Poizoni A/B

Clostridium difficile (CD) ndi bacillus yovomerezeka ya anaerobic gram-positive, yomwe ndi zomera wamba m'thupi la munthu. Zomera zina zimalepheretsedwa kuchulukitsa chifukwa cha maantibayotiki omwe amagwiritsidwa ntchito pamlingo waukulu, ndipo CD imaberekana m'thupi la munthu mochuluka. CD imagawidwa m'magulu awiri opanga poizoni ndi osapanga poizoni. Mitundu yonse ya CD imapanga glutamate dehydrogenase (GDH) ikaberekana, ndipo mitundu yokha ya poizoni ndi yomwe imapha tizilombo toyambitsa matenda. Mitundu yopanga poizoni imatha kupanga poizoni awiri, A ndi B. Toxin A ndi enterotoxin, yomwe ingayambitse kutupa kwa khoma la m'mimba, kulowa kwa maselo, kuwonjezeka kwa kulowa kwa khoma la m'mimba, kutuluka magazi ndi necrosis. Toxin B ndi cytotoxin, yomwe imawononga cytoskeleton, imayambitsa cell pyknosis ndi necrosis, ndipo imawononga mwachindunji maselo a m'mimba, zomwe zimapangitsa kutsegula m'mimba ndi pseudomembranous colitis.