Clostridium Difficile Glutamate Dehydrogenase(GDH) ndi Toxin A/B

Clostridium difficile(CD) ndi bacillus ya anaerobic gram-positive, yomwe ndi zomera zachibadwa m'thupi la munthu. Zomera zina zidzalepheretsedwa kuchulukirachulukira chifukwa cha maantibayotiki omwe amagwiritsidwa ntchito kwambiri, ndipo ma CD amachulukanso m'thupi la munthu. CD imagawidwa m'mitundu yotulutsa poizoni komanso yosapanga poizoni. Mitundu yonse ya ma CD imatulutsa glutamate dehydrogenase (GDH) ikachulukana, ndipo mitundu yokhayo ya toxigenic ndiyomwe imayambitsa matenda. Mankhwala opangira poizoni amatha kutulutsa poizoni awiri, A ndi B. Poizoni A ndi enterotoxin, yomwe ingayambitse kutupa kwa khoma la m'mimba, kulowetsedwa kwa selo, kuwonjezeka kwa matumbo a m'mimba, kutaya magazi ndi necrosis. Poizoni B ndi cytotoxin, yomwe imawononga cytoskeleton, imayambitsa cell pyknosis ndi necrosis, ndipo imawononga mwachindunji maselo am'mimba a parietal, zomwe zimapangitsa kutsekula m'mimba ndi pseudomembranous colitis.