Chithandizo cha Aspirin Chitetezo

Aspirin, monga mankhwala oletsa kuphatikizika kwa mapulateleti, amagwiritsidwa ntchito kwambiri popewa komanso kuchiza matenda a mtima ndi cerebrovascular. Kafukufukuyu apeza kuti odwala ena apezeka kuti sangathe kuletsa bwino ntchito ya mapulateleti ngakhale akugwiritsa ntchito aspirin kwa nthawi yayitali, ndiko kuti, aspirin kukana (AR). Mlingo ndi pafupifupi 50% -60%, ndipo pali zoonekeratu kusiyana mitundu. Glycoprotein IIb/IIIa (GPI IIb/IIIa) imagwira ntchito yofunikira pakuphatikizana kwa mapulateleti komanso kugunda kwa mtima pachimake pamasamba ovulala kwamitsempha. Kafukufuku wasonyeza kuti ma gene polymorphisms amagwira ntchito yofunikira pakukana kwa aspirin, makamaka kuyang'ana pa GPIIIa P1A1/A2, PEAR1 ndi PTGS1 gene polymorphisms. GPIIa P1A2 ndiye jini yayikulu yolimbana ndi aspirin. Kusintha kwa jini iyi kumasintha mawonekedwe a GPIIb/IIIa receptors, zomwe zimapangitsa kulumikizana pakati pa mapulateleti ndi kuphatikiza kwa mapulateleti. Kafukufukuyu adapeza kuti mafupipafupi a P1A2 alleles mwa odwala omwe samva aspirin anali apamwamba kwambiri kuposa omwe ali ndi vuto la aspirin, ndipo odwala omwe ali ndi kusintha kwa P1A2 / A2 homozygous anali ndi vuto losagwira bwino atamwa aspirin. Odwala omwe ali ndi P1A2 alleles omwe akukumana ndi stenting amakhala ndi chiwerengero cha subacute thrombotic chochitika chomwe chimakhala kasanu kuposa cha P1A1 homozygous odwala amtundu wa zakutchire, zomwe zimafuna mlingo waukulu wa aspirin kuti akwaniritse zotsatira za anticoagulant. PEAR1 GG allele imayankha bwino aspirin, ndipo odwala omwe ali ndi AA kapena AG genotype omwe amamwa aspirin (kapena kuphatikiza ndi clopidogrel) pambuyo pa kuikidwa kwa stent amakhala ndi infarction yapamwamba ya myocardial ndi imfa. PTGS1 GG genotype ili ndi chiopsezo chachikulu cha aspirin kukana (HR: 10) komanso zochitika zambiri zamtima (HR: 2.55). AG genotype ili ndi chiwopsezo chocheperako, ndipo tcheru kwambiri chiyenera kuperekedwa ku zotsatira za chithandizo cha aspirin. AA genotype imakhudzidwa kwambiri ndi aspirin, ndipo zochitika za mtima wamtima ndizochepa. Zotsatira zodziwika za mankhwalawa zimangoyimira zotsatira za chibadwa chamunthu PEAR1, PTGS1, ndi GPIIIa.